Phenotypes associated with this allele

• Allele Symbol: Tg(Mt1-Tgfa)147Bri
• Allele Name: transgene insertion 147, Ralph L Brinster
• Allele ID: MGI:3040323
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Mt1-Tgfa)147Bri/0	involves: C57BL/6 * SJL	MGI:3800660

Genotype
MGI:3800660

tg1

• Allelic Composition: Tg(Mt1-Tgfa)147Bri/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:56318 )

• female mice die by 9.5 months of age

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:56318 )

♀ • severely delayed

increased mammary gland tumor incidence ( J:56318 )

• female mice develop mammary gland tumors and die by 9.5 months of age

• however, virgin females do not develop mammary gland tumors

• female mice develop well differentiated microcystic/glandular adenomas or carcinomas and papillary adenocarcinomas that resemble normal pregnant and lactating mammary epitherlium as well as fibroadenomas and occasionally solid carcinomas that do not resemble a normal mammary gland

• 17% of tumors are glandular/microcystic foci combined with papillary, fibroadenomatous or solid foci

• while lung metastasis is rare, most tumors are transplantable

increased mammary adenocarcinoma incidence ( J:56318 )

• most tumors are well differentiated adenomas and adenocarcinomas

mammary gland hyperplasia ( J:56318 )

♀ • glandular hyperplasia worsens with each pregnancy resulting in the creation of numerous hyperplastic alveolar nodules resembling tumors

neoplasm

increased mammary gland tumor incidence ( J:56318 )

• female mice develop mammary gland tumors and die by 9.5 months of age

• however, virgin females do not develop mammary gland tumors

• female mice develop well differentiated microcystic/glandular adenomas or carcinomas and papillary adenocarcinomas that resemble normal pregnant and lactating mammary epitherlium as well as fibroadenomas and occasionally solid carcinomas that do not resemble a normal mammary gland

• 17% of tumors are glandular/microcystic foci combined with papillary, fibroadenomatous or solid foci

• while lung metastasis is rare, most tumors are transplantable

increased mammary adenocarcinoma incidence ( J:56318 )

• most tumors are well differentiated adenomas and adenocarcinomas

integument

abnormal involution of the mammary gland ( J:56318 )

♀ • severely delayed

increased mammary gland tumor incidence ( J:56318 )

• while lung metastasis is rare, most tumors are transplantable

• 17% of tumors are glandular/microcystic foci combined with papillary, fibroadenomatous or solid foci

• female mice develop mammary gland tumors and die by 9.5 months of age

• however, virgin females do not develop mammary gland tumors

• female mice develop well differentiated microcystic/glandular adenomas or carcinomas and papillary adenocarcinomas that resemble normal pregnant and lactating mammary epitherlium as well as fibroadenomas and occasionally solid carcinomas that do not resemble a normal mammary gland

increased mammary adenocarcinoma incidence ( J:56318 )

• most tumors are well differentiated adenomas and adenocarcinomas

mammary gland hyperplasia ( J:56318 )

♀ • glandular hyperplasia worsens with each pregnancy resulting in the creation of numerous hyperplastic alveolar nodules resembling tumors