All Phenotypes Ebf3<tm1Reed> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ebf3^tm1Reed
targeted mutation 1, Randall R Reed
MGI:3037961

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ebf3^tm1Reed/Ebf3^tm1Reed	involves: 129S1/Sv * 129X1/SvJ	MGI:3038081
cx2	Ebf2^tm1Reed/Ebf2⁺ Ebf3^tm1Reed/Ebf3⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3038083

Allelic Composition	Ebf3^tm1Reed/Ebf3^tm1Reed
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf3^tm1Reed mutation (0 available); any Ebf3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:88585 )

• most mice died within 1 day of birth, with the rest dying by postnatal day 2

nervous system

small olfactory bulb ( J:88585 )

abnormal sensory neuron innervation pattern ( J:88585 )

Allelic Composition	Ebf2^tm1Reed/Ebf2⁺ Ebf3^tm1Reed/Ebf3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2^tm1Reed mutation (0 available); any Ebf2 mutation (30 available)
Ebf3^tm1Reed mutation (0 available); any Ebf3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:88585 )

N	• unlike either Ebf2^tm1Reed and Ebf3^tm1Reed homozygotes, the olfactory bulb is of normal size and shape

abnormal olfactory neuron innervation pattern ( J:88585 )

• olfactory neurons fail to project to the dorsal olfactory bulb

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