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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Qkie5
quaking e5
MGI:3037830
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Qkie5/Qkie5 B6.101Rl-Qkie5 MGI:3607583
ht2
 		Qkie5/Qkiqk-kt1 involves: 101/Rl * C57BL/6J MGI:3607584
ht3
 		Qkie5/Qkiqk-k2 involves: 101/Rl * C57BL/6J * CBA/Ca MGI:3607586


Genotype
MGI:3607583
hm1
Allelic
Composition		 Qkie5/Qkie5
Genetic
Background		 B6.101Rl-Qkie5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qkie5 mutation (0 available); any Qki mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Brain morphology in Qkie5/Qkie5 and Qkiqk-v/Qkiqk-v mice

mortality/aging
premature death ( J:102038 )
• only about 35% survive to 5 months of age

behavior/neurological
tremors ( J:102038 )
• quaking behavior first appears around 10 days of age
ataxia ( J:102038 )
• develop progressive, severe ataxia by 2.5-3 months of age
seizures ( J:102038 )
• induced by slight noise or general handling
• first appear as early as 18 days of age

nervous system
seizures ( J:102038 )
• first appear as early as 18 days of age
• induced by slight noise or general handling
abnormal brain white matter morphology ( J:102038 )
• lack of white matter in both anterior and posterior portions of brain
Purkinje cell degeneration ( J:102038 )
• Purkinji cell axonal swelling indicative of neurodegeneration by 3 months of age
abnormal oligodendrocyte morphology ( J:102038 )
• myelin sheaths with only a few lamellae
abnormal myelination ( J:102038 )
• myelin sparse or absent in the brain
• myelin sheaths with only a few lamellae




Genotype
MGI:3607584
ht2
Allelic
Composition		 Qkie5/Qkiqk-kt1
Genetic
Background		 involves: 101/Rl * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qkie5 mutation (0 available); any Qki mutation (26 available)
Qkiqk-kt1 mutation (0 available); any Qki mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
seizures ( J:102038 )
• but no ataxia

nervous system
seizures ( J:102038 )
• but no ataxia




Genotype
MGI:3607586
ht3
Allelic
Composition		 Qkie5/Qkiqk-k2
Genetic
Background		 involves: 101/Rl * C57BL/6J * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qkie5 mutation (0 available); any Qki mutation (26 available)
Qkiqk-k2 mutation (1 available); any Qki mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:102038 )
N
• mice live beyond 5 months of age

behavior/neurological
seizures ( J:102038 )
• but no ataxia

nervous system
seizures ( J:102038 )
• but no ataxia




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory