Phenotypes associated with this allele

• Allele Symbol: Qki^tm1Imeg
• Allele Name: targeted mutation 1, Institute of Molecular Embryology and Genetics
• Allele ID: MGI:3033861
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Qki^tm1Imeg/Qki^tm1Imeg	involves: 129P2/OlaHsd	MGI:3033873

Genotype
MGI:3033873

hm1

• Allelic Composition: Qki^tm1Imeg/Qki^tm1Imeg
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:88215 )

• by E9.5 all homozygous embryos exhibited abnormalities

• homozygotes died in utero between E9.5 and E10.5

cardiovascular system

abnormal blood vessel morphology ( J:88215 )

• lack of alpha smooth muscle actin in blood vessels

• vascular remodeling is incomplete

• vascular network over the brain lacks complexity

abnormal vitelline vasculature morphology ( J:88215 )

• vitelline artery is irregular within the body and tapers off to contact point with yolk sac

• no large vitelline vessels on the yolk sac but a primary vitelline plexus present

abnormal heart morphology ( J:88215 )

abnormal myocardium layer morphology ( J:88215 )

• slightly reduced levels of alpha smooth muscle actin

pericardial effusion ( J:88215 )

embryo

abnormal vitelline vasculature morphology ( J:88215 )

• vitelline artery is irregular within the body and tapers off to contact point with yolk sac

• no large vitelline vessels on the yolk sac but a primary vitelline plexus present

incomplete embryo turning ( J:88215 )

• incomplete turning observed in 7.7% of embryos

decreased embryo size ( J:88215 )

• slightly smaller than normal at E9.5 (17 vs. 19 somites)

abnormal neural tube morphology ( J:88215 )

open neural tube ( J:88215 )

wavy neural tube ( J:88215 )

• "kinky" neural tubes

growth/size/body

decreased embryo size ( J:88215 )

• slightly smaller than normal at E9.5 (17 vs. 19 somites)

hematopoietic system

abnormal hematopoietic system morphology/development ( J:88215 )

• embryos are pale although blood is present in the yolk sac

nervous system

abnormal neural tube morphology ( J:88215 )

open neural tube ( J:88215 )

wavy neural tube ( J:88215 )

• "kinky" neural tubes

homeostasis/metabolism

pericardial effusion ( J:88215 )

muscle

abnormal myocardium layer morphology ( J:88215 )

• slightly reduced levels of alpha smooth muscle actin