Phenotypes associated with this allele

• Allele Symbol: Igh^tm1Tim
• Allele Name: targeted mutation 1, Tim Manser
• Allele ID: MGI:3032982
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Igh-J^tm1Dhu/Igh^tm1Tim	involves: 129X1/SvJ * C57BL/6	MGI:3033131

Genotype
MGI:3033131

cx1

• Allelic Composition: Igh-J^tm1Dhu/Igh^tm1Tim
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell morphology ( J:87624 )

• cell surface IgM levels are generally lower and particularly lower in E4+ cells

• cell surface IgD levels are normal except in E4+ cells where it is dramatically reduced

• lambda-L chain levels were elevated 3X generally but were undetectable in E4+ B cells

abnormal B cell differentiation ( J:88410 )

• B cell development was normal in bone marrow

• splenic B cells with a follicular phenotype and are E4+

• B cells do not express endogenous mu-chain

abnormal spleen morphology ( J:87624 )

abnormal spleen marginal zone morphology ( J:87624 )

• B cell area decreased in size

immune system

abnormal B cell morphology ( J:87624 )

• cell surface IgM levels are generally lower and particularly lower in E4+ cells

• cell surface IgD levels are normal except in E4+ cells where it is dramatically reduced

• lambda-L chain levels were elevated 3X generally but were undetectable in E4+ B cells

abnormal B cell differentiation ( J:88410 )

• B cell development was normal in bone marrow

• splenic B cells with a follicular phenotype and are E4+

• B cells do not express endogenous mu-chain

abnormal immune system organ morphology ( J:87624 )

abnormal spleen morphology ( J:87624 )

abnormal spleen marginal zone morphology ( J:87624 )

• B cell area decreased in size