Phenotypes associated with this allele

• Allele Symbol: Adar^tm1Knk
• Allele Name: targeted mutation 1, Kazuko Nishikura
• Allele ID: MGI:3032439
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Adar^tm1Knk/Adar^tm1Knk Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA	MGI:3032498

Genotype
MGI:3032498

cn1

• Allelic Composition: Adar^tm1Knk/Adar^tm1Knk; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased apoptosis in liver of Adar^tm1Knk/Adar^tm1Knk Speer6-ps1^{Tg(Alb-cre)21Mgn}/0 mice

hematopoietic system

hematopoietic system phenotype ( J:87714 )

N • no observed hematopoietic defects

homeostasis/metabolism

hyperglycemia ( J:87714 )

abnormal circulating enzyme level ( J:87714 )

• increased levels of enzymes indicating hepatocellular damage

increased circulating alanine transaminase level ( J:87714 )

increased circulating alkaline phosphatase level ( J:87714 )

increased circulating aspartate transaminase level ( J:87714 )

increased circulating lactate dehydrogenase level ( J:87714 )

liver/biliary system

increased hepatocyte apoptosis ( J:87714 )

• increased apoptosis among hepatocytes

abnormal liver morphology ( J:87714 )

• disorganized liver architecture at 6 weeks of age

cellular

increased hepatocyte apoptosis ( J:87714 )

• increased apoptosis among hepatocytes

growth/size/body

decreased body size ( J:87714 )

• body size about 50-70% of controls