Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adartm2Phs mutation
(0 available);
any
Adar mutation
(71 available)
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hematopoietic system
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• the frequency and absolute number of Lin- c-Kit+Sca-1- hematopoietic stem cell in the E11.5 fetal liver is much lower than controls
• the frequency but not absolute number of Lin- c-Kit+Sca-1+ hematopoietic stem cell in the E11.5 fetal liver is much higher than controls
• similar differences in HSC frequencies are observed when AA4.1 is used as a marker instead of c-Kit
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homeostasis/metabolism
immune system
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• extracellular fluid from E11.5 embryos that have had their livers removed has 13-fold more interferon-alpha than controls
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• extracellular fluid from E11.5 embryos that have had their livers removed has 80-fold more interferon-beta than controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adartm2Phs mutation
(0 available);
any
Adar mutation
(71 available)
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mortality/aging
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• death between E11.5 and E12.5
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embryo
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• slightly retarded development prior to death around E12
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hematopoietic system
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• reduced in the fetal liver
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• cell numbers in mutant embryonic hematopoietic tissues were significantly reduced in the yolk sac (to 52%), fetal liver (to 42%), and peripheral blood (to 63%) compared with control embryos
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liver/biliary system
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• disintegrating liver structure with reduced cell density evident at E11.5
• often blood accumulation in pathologically enlarged spaces
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• significant size reduction of fetal liver evident at E12
• fetal liver size was normal until E11-E11.25
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growth/size/body
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• slightly retarded development prior to death around E12
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adartm2Phs mutation
(0 available);
any
Adar mutation
(71 available)
|
|
|
mortality/aging
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• death between E11.5 and E12.5
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embryo
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• slightly retarded development prior to death around E12
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hematopoietic system
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• reduced in the fetal liver
|
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• cell numbers in mutant embryonic hematopoietic tissues were significantly reduced in the yolk sac (to 52%), fetal liver (to 42%), and peripheral blood (to 63%) compared with control embryos
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liver/biliary system
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• disintegrating liver structure with reduced cell density evident at E11.5
• often blood accumulation in pathologically enlarged spaces
|
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• significant size reduction of fetal liver evident at E12
• fetal liver size was normal until E11-E11.25
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growth/size/body
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• slightly retarded development prior to death around E12
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adartm1.1Phs mutation
(2 available);
any
Adar mutation
(71 available)
Adartm2Phs mutation
(0 available);
any
Adar mutation
(71 available)
Tg(Tal1-cre/ERT)42-056Jrg mutation
(2 available)
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hematopoietic system
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• bone marrow cellularity is reduced in mice after cre induction
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• the frequency of Lin- c-Kit+Sca-1- hematopoietic stem cells (HSC) in the bone marrow after cre induction is much lower than controls
• the frequency of Lin- c-Kit+Sca-1+ HSC in the bone marrow after cre induction is much higher than controls
• 68% of actively cycling HSCs are apoptotic after cre induction versus 3-13% in control mice
• the bone marrow has many fewer Lin- c-Kit+Sca-1+CD34lo HSC cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adartm1.1Phs mutation
(2 available);
any
Adar mutation
(71 available)
Adartm2Phs mutation
(0 available);
any
Adar mutation
(71 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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mortality/aging
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• mice die shortly after birth, even in the absence of cre induction by poly(I:C) administration
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hematopoietic system
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• E14.5 fetal liver cells transplanted into wild-type hosts engraft normally but fail to replenish blood leukocytes after cre induction
• two weeks after cre induction, the contribution of the mutant cells to blood leukocytes is diminished by a fourth
• the contribution of these fetal liver cells to peripheral blood cells including myeloid, B-lymphoid and T-lymphoid lineages is negligible after 23 weeks of cre induction
• very few donor derived hematopoetic stem cells are found in the bone marrow after 23 weeks of cre induction
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liver/biliary system
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• E14.5 embryos have slightly lower total liver cellularity even in the absence of cre induction by poly(I:C) administration
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