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Allele Symbol Allele Name Allele ID |
Stat3tm1Dnl targeted mutation 1, James E Darnell MGI:3028651 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 75% die within 48 hours of birth
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• mice surviving the first week of age reach only 50-60% of normal size, however by 8 weeks of age, they are only about 10% smaller than normal
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• body weight is 85% to 90% that of wild-type at birth
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• growth retardation starts during late fetal development
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• decrease in thymocytes number at 7 days and 6 months of age associated with increased apoptosis
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• decrease in thymocytes number at 7 days and 6 months of age associated with increased apoptosis
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• decrease in serum insulin-like growth factor 1 levels at P8 and P24 but higher levels in newborns
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• growth hormone levels at 24 days of age are reduced in males but not in females
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• decrease in major urinary protein in the urine
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• decrease in major urinary protein in the urine
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• decrease in thymocytes number at 7 days and 6 months of age associated with increased apoptosis
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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