Phenotypes associated with this allele

• Allele Symbol: Ss18l1^tm1Ghsh
• Allele Name: targeted mutation 1, Anirvan Ghosh
• Allele ID: MGI:3028533
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ss18l1^tm1Ghsh/Ss18l1^tm1Ghsh	Not Specified	MGI:3028537
cx2	Ss18^tm1Adg/Ss18^+ Ss18l1^tm1Ghsh/Ss18l1^tm1Ghsh	involves: 129 * C57BL/6	MGI:3691344

Genotype
MGI:3028537

hm1

• Allelic Composition: Ss18l1^tm1Ghsh/Ss18l1^tm1Ghsh
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:87443 )

• increased mortality starting about day 14

• 80% dead by day 28

behavior/neurological

impaired coordination ( J:87443 )

growth/size/body

decreased body size ( J:87443 )

• although indistinguishable from wild-type at birth, homozygotes grew more slowly

reproductive system

infertility ( J:87443 )

• of the less than 20% who survived to adulthood, all were infertile

nervous system

abnormal forebrain morphology ( J:87443 )

• dendritic growth and branching compromised by day 7

abnormal hippocampus CA3 region morphology ( J:87443 )

• dendritic length reduced 50-80% in hippocampal CA3 neurons

abnormal cerebral cortex morphology ( J:87443 )

• cortex is reduced in size

• dendritic length reduced 50-80% in cortical layer 5

• dendritic branching in cortical neurons is reduced

abnormal hindbrain morphology ( J:87443 )

small cerebellum ( J:87443 )

Genotype
MGI:3691344

cx2

• Allelic Composition: Ss18^tm1Adg/Ss18⁺; Ss18l1^tm1Ghsh/Ss18l1^tm1Ghsh
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

perinatal lethality, complete penetrance ( J:114839 )

• mutants are identified at E9.5 and E18.5 but not after birth, indicating perinatal lethality