Analysis Tools
renal/urinary system
| N |
• mice show normal kidney morphology and a normal response to kidney ischemia/reperfusion injury
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Allele Symbol Allele Name Allele ID |
Sema4dtm1Kik targeted mutation 1, Hitoshi Kikutani MGI:3027762 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice show normal kidney morphology and a normal response to kidney ischemia/reperfusion injury
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• neither defects in the cerebellum nor ectopic granule cells are observed despite being a possible ligand for Plxnb2
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• behavior was normal
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| N |
• Phenotype was normal in these tissues where Sema4dtm1Kik interacts through plexin-B1 receptors rather than through CD72 receptors as in lymphoid tissue
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• cell proliferation was slower in vitro
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• increased numbers of CD23+B220+ B cells
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• Il4 and Ifn-gamma T-cells reduced in numbers
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• reduced in numbers
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• B-1 cell development abnormality
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• considerable reduction in numbers of CD5+B220+ B cells
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• germinal centers in the spleen were smaller and with fewer antigen specific IgG1 cells
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• impaired IgG1 response to T-cell dependent antigen but not to T-cell independent antigens
• no abnormalities in serum levels of the various Ig classes however
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• cell proliferation was slower in vitro
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• increased numbers of CD23+B220+ B cells
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• Il4 and Ifn-gamma T-cells reduced in numbers
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• reduced in numbers
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• B-1 cell development abnormality
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• considerable reduction in numbers of CD5+B220+ B cells
|
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• germinal centers in the spleen were smaller and with fewer antigen specific IgG1 cells
|
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• impaired IgG1 response to T-cell dependent antigen but not to T-cell independent antigens
• no abnormalities in serum levels of the various Ig classes however
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| N |
• Phenotype was normal in these tissues where Sema4dtm1Kik interacts through plexin-B1 receptors rather than through CD72 receptors as in lymphoid tissue
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| N |
• Phenotype was normal in these tissues where Sema4dtm1Kik interacts through plexin-B1 receptors rather than through CD72 receptors as in lymphoid tissue
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• cell proliferation was slower in vitro
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following renal ischemia/reperfusion injury, mice exhibit misorganized, multi-layered tubular kidney epithelium compared to controls
• tubular defects after kidney injury are confined to the outer renal medulla
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• following renal ischemia/reperfusion injury, mice exhibit misorganized, multi-layered tubular kidney epithelium compared to controls
• tubular defects after kidney injury are confined to the outer renal medulla
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• following renal ischemia/reperfusion injury, mice exhibit misorganized, multi-layered tubular kidney epithelium compared to controls
• however, mice are viable and show no overt defects in kidney histology under normal conditions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• neither defects in the cerebellum nor ectopic granule cells are observed despite being possible ligands for Plxnb2
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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