Phenotypes associated with this allele

• Allele Symbol: Hc⁰
• Allele Name: deficient
• Allele ID: MGI:3027637
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hc^0/Hc^0	B10.D2-Hc^0	MGI:3714384
hm2	Hc^0/Hc^0	B10.D2-Hc^0 H2^d H2-T18^c/oSnJ	MGI:3806150
hm3	Hc^0/Hc^0	involves: A/J * C3H/HeJ	MGI:3623810
hm4	Hc^0/Hc^0	involves: C57BL/10SnJ	MGI:3663127
cx5	Hc^0/Hc^0 Tg(TcrbBL17)1Lmor/0	involves: DBA/1J * SWR/J	MGI:3790651

Genotype
MGI:3714384

hm1

• Allelic Composition: Hc⁰/Hc⁰
• Genetic Background: B10.D2-Hc⁰

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to injury ( J:120567 )

• mice are resistant to ischemia reperfusion-induced renal injury

• serum urea nitrogen is reduced 35% to 40% compared to wild-type mice subjected to ischemia reperfusion

liver/biliary system

liver fibrosis ( J:100159 )

• resistance to hepatic fibrosis

• less advanced stages of liver fibrosis

• reduced hepatic collagen concentrations

Genotype
MGI:3806150

hm2

• Allelic Composition: Hc⁰/Hc⁰
• Genetic Background: B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:128218 )

N • mice exhibit normal ethanol-induced liver steatosis

decreased susceptibility to injury ( J:128218 )

• following exposure to ethanol, mice do not exhibit an increase in alanine aminotransferase, TNF-alpha, IL6 and IFN-gamma as in similarly treated wild-type mice

Genotype
MGI:3623810

hm3

• Allelic Composition: Hc⁰/Hc⁰
• Genetic Background: involves: A/J * C3H/HeJ

respiratory system

increased airway responsiveness ( J:108211 )

• susceptibility to allergen-induced bronchial hyperresponsiveness

Genotype
MGI:3663127

hm4

• Allelic Composition: Hc⁰/Hc⁰
• Genetic Background: involves: C57BL/10SnJ

immune system

increased susceptibility to bacterial infection ( J:44240 )

• Hc-deficient mice display a 25-fold reduction in bacterial clearance after 1 and 3 hours after CLP compared to control mice

Genotype
MGI:3790651

cx5

• Allelic Composition: Hc⁰/Hc⁰; Tg(TcrbBL17)1Lmor/0
• Genetic Background: involves: DBA/1J * SWR/J

immune system

decreased susceptibility to induced arthritis ( J:134111 )

• resistance to collagen-induced arthritis

skeleton

decreased susceptibility to induced arthritis ( J:134111 )

• resistance to collagen-induced arthritis