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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Artm1.1Chc
targeted mutation 1.1, Chawnshang Chang
MGI:2687199
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Artm1.1Chc/Artm1.1Chc involves: 129S/SvEv * C57BL/6 * FVB/N MGI:3775038
cn2
 		Artm1Chc/Artm1.1Chc
Tmem163Tg(ACTB-cre)2Mrt/0 		involves: 129S/SvEv * C57BL/6J * FVB/N MGI:3773446
ot3
 		Artm1.1Chc/Y involves: 129S/SvEv * C57BL/6 * FVB/N MGI:3773633


Genotype
MGI:3775038
hm1
Allelic
Composition		 Artm1.1Chc/Artm1.1Chc
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1.1Chc mutation (0 available); any Ar mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of tumors by chemical induction ( J:120844 )
• after treatment with the genotoxic bladder carcinogen BBN, no null females develop carcinomas whereas 42% of treated females have bladder carcinomas by 40 weeks post-treatment
preneoplasia ( J:120844 )
• only 2 females display preneoplastic lesions (hyperplasias) of the bladder by 40 weeks following treatment compared to 67% of wild-type females

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:120844 )
• after treatment with the genotoxic bladder carcinogen BBN, no null females develop carcinomas whereas 42% of treated females have bladder carcinomas by 40 weeks post-treatment




Genotype
MGI:3773446
cn2
Allelic
Composition		 Artm1Chc/Artm1.1Chc
Tmem163Tg(ACTB-cre)2Mrt/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1.1Chc mutation (0 available); any Ar mutation (22 available)
Artm1Chc mutation (0 available); any Ar mutation (22 available)
Tmem163Tg(ACTB-cre)2Mrt mutation (3 available); any Tmem163 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased ovary weight ( J:87193 )
• ovaries from 4-, 6-, and 12-week old females weigh 18-23% less than those of control females
decreased oviduct weight ( J:87193 )
• oviducts from 4-, 6-, and 12-week old females weigh 18-23% less than those of control females
decreased uterus weight ( J:87193 )
• uterI from 4-, 6-, and 12-week old females weigh 18-23% less than in control females
decreased litter size ( J:81789 )
• litters from homozygous females are have fewer pups compared to those of control females

behavior/neurological
abnormal nursing ( J:87193 )
• some mutant females display reluctant nursing behavior

endocrine/exocrine glands
enlarged thymus ( J:87193 )
• thymus in female mice is larger than in control females
abnormal mammary gland morphology ( J:87193 )
• mammary glands in 4-, 6-, and 12-week old females weigh 18-23% less than in control female littermates
abnormal branching of the mammary ductal tree ( J:87193 )
• by fourth to sixth weeks of age, ductal system has 30-50% less extension with reduced numbers of terminal end buds than in control females
• at maturity (8, 16 and 20 weeks) mammary glands are filled with large bloated ducts terminating with bloated ends; glands have fewer secondary and tertiary ductal branches compared to controls; during pregnancy, retarded ductal branches are partially restored, but mutant mammary glands still have less milk-producing alveoli than control glands
decreased ovary weight ( J:87193 )
• ovaries from 4-, 6-, and 12-week old females weigh 18-23% less than those of control females
abnormal lactation ( J:87193 )
• retardation of mammary gland development may affect capacity of females to provide milk for their offspring

hematopoietic system
enlarged thymus ( J:87193 )
• thymus in female mice is larger than in control females

immune system
enlarged thymus ( J:87193 )
• thymus in female mice is larger than in control females

integument
abnormal mammary gland morphology ( J:87193 )
• mammary glands in 4-, 6-, and 12-week old females weigh 18-23% less than in control female littermates
abnormal branching of the mammary ductal tree ( J:87193 )
• by fourth to sixth weeks of age, ductal system has 30-50% less extension with reduced numbers of terminal end buds than in control females
• at maturity (8, 16 and 20 weeks) mammary glands are filled with large bloated ducts terminating with bloated ends; glands have fewer secondary and tertiary ductal branches compared to controls; during pregnancy, retarded ductal branches are partially restored, but mutant mammary glands still have less milk-producing alveoli than control glands
abnormal lactation ( J:87193 )
• retardation of mammary gland development may affect capacity of females to provide milk for their offspring




Genotype
MGI:3773633
ot3
Allelic
Composition		 Artm1.1Chc/Y
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1.1Chc mutation (0 available); any Ar mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
small testis ( J:89886 )
• much smaller than wild-type and smaller than in males with Sertoli cell-specific Ar-deficiency
arrest of spermatogenesis ( J:89886 )
• spermatogenesis is arrested at the pachytene stage

endocrine/exocrine glands
small testis ( J:89886 )
• much smaller than wild-type and smaller than in males with Sertoli cell-specific Ar-deficiency

homeostasis/metabolism
decreased circulating testosterone level ( J:89886 )
• mutant males have lower serum testosterone levels than wild-type males or males with Sertoli cell-specific Ar-deficiency
increased circulating luteinizing hormone level ( J:89886 )
• LH levels are increased in serum than wild-type males
decreased incidence of tumors by chemical induction ( J:120844 )
• after treatment with the genotoxic bladder carcinogen BBN, no null males develop carcinomas whereas all wild-type males show invasive bladder carcinoma by 30 weeks after treatment
• however, treatment with BBN and dihydroxytestosterone (DHT) results in 25% of males developing bladder carcinoma by 40 weeks

neoplasm
decreased incidence of tumors by chemical induction ( J:120844 )
• after treatment with the genotoxic bladder carcinogen BBN, no null males develop carcinomas whereas all wild-type males show invasive bladder carcinoma by 30 weeks after treatment
• however, treatment with BBN and dihydroxytestosterone (DHT) results in 25% of males developing bladder carcinoma by 40 weeks
abnormal tumor morphology ( J:120844 )
• BBN-induced bladder tumors in DHT-treated males have lower proliferation indices and higher apoptotic index than BBN-treated wild-type, BBN-treated castrated wild-type malesand BBN only-treated males
preneoplasia ( J:120844 )
• only 2 males display preneoplastic lesions (hyperplasias) of the bladder by 40 weeks following treatment compared to 75% of wild-type
• however, treatment with BBN and dihydroxytestosterone (DHT) results in 40% of treated males showing preneoplastic lesions by 40 weeks




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory