Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngr1tm1Dmer mutation
(0 available);
any
Ifngr1 mutation
(52 available)
Tg(Thy1-cre)1Vln mutation
(1 available)
|
|
|
immune system
|
|
• mice fail to develop viral deja vu disease unlike wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Panx1tm1Vshe mutation
(1 available);
any
Panx1 mutation
(37 available)
Tg(Thy1-cre)1Vln mutation
(1 available)
|
|
|
nervous system
|
|
• following ischemia/reperfusion injury
|
|
|
• following ischemia/reperfusion injury
|
homeostasis/metabolism
vision/eye
|
|
• following ischemia/reperfusion injury
|
cellular
|
|
• following ischemia/reperfusion injury
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dscamtm1Pfu mutation
(1 available);
any
Dscam mutation
(105 available)
Tg(Thy1-cre)1Vln mutation
(1 available)
|
|
|
vision/eye
|
|
• aggregation of recombined retinal ganglion cells
|
nervous system
|
|
• aggregation of recombined retinal ganglion cells
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dctn1tm2.1Cai mutation
(1 available);
any
Dctn1 mutation
(64 available)
Tg(Thy1-cre)1Vln mutation
(1 available)
|
|
|
behavior/neurological
|
|
• hindlimb clasping is observed in 18 month old mice
|
|
|
• less time spent on rotating rods as compared to controls at 12 months of age
|
|
|
• reduced rearing is observed by 18 months of age
|
cellular
|
|
• increased cell death in neurons after treatment with 10um glutamate
• increase in total and cell surface levels of glutamate receptors
|
|
|
• increase in autophagosome/lysosome proteins in spinal motor neuron axons of 9 month old mice
|
hematopoietic system
|
|
• increased astrogliosis and microgliosis is observed in the spinal cord of 18 month old mice
|
homeostasis/metabolism
immune system
|
|
• increased astrogliosis and microgliosis is observed in the spinal cord of 18 month old mice
|
muscle
 |
• decrease in gastrocnemius muscle weight in 24 month old males
|
|
|
• myofiber de/regeneration, decrease in size of muscle fiber, and inflammatory cell infiltration of gastrocnemius muscle in 24 month old males
|
nervous system
|
|
• increased cell death in neurons after treatment with 10um glutamate
• increase in total and cell surface levels of glutamate receptors
|
|
|
• increased astrogliosis and microgliosis is observed in the spinal cord of 18 month old mice
|
|
|
• increased astrogliosis and microgliosis is observed in the spinal cord of 18 month old mice
|
|
|
• accumulation of acetylated alpha-tubulin in spinal motor neuron axons of 9 month old mice
|
|
|
• decrease in numbers of spinal motor neurons in lumbar spinal cord in 18 month, but not 9 month old mice
|
|
|
• neuromuscular junctions (NMJ) in 18 month old mice are partially or fully fragmented
• severe denervation in NMJ of 18 month old mice
|
limbs/digits/tail
|
|
• decrease in gastrocnemius muscle weight in 24 month old males
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation
(2 available);
any
Psen1 mutation
(46 available)
Tg(Thy1-APPLon)2Vln mutation
(0 available)
Tg(Thy1-cre)1Vln mutation
(1 available)
|
|
|
behavior/neurological
|
|
• retention of object recognition is normal at 1 hr after training but testing of animals 3 hours after familiarization with an object reveals significant impairment relative to controls
|
nervous system
|
N |
• no thioflavin-S-reactive amyloid plaques or diffuse amyloid deposits are detected in mice up to 18 months of age
|
|
|
• with tetanic stimulation of hippocampal slices, after an initial slight decrease, the slope of the fEPSP approached control levels; LTP in transgenic brain slices is comparable to controls
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation
(2 available);
any
Psen1 mutation
(46 available)
Tg(Thy1-cre)1Vln mutation
(1 available)
|
|
|
behavior/neurological
|
N |
• mice do not display any behavioral or cognitive deficits
|
nervous system
|
N |
• brains of 6 month-old mice do not show any morphological abnormalities like cerebral hemorrhages, cavities or tumors; no defects are observed up to 2 years of age
|
|
|
• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains
|
|
|
• initial phase of the slope of fEPSP is lower (168% vs 221% in controls) 15 minutes after tetanic stimulation; slope of fEPSP progressively increases to approach control levels 2 hours following stimulation
|
homeostasis/metabolism
Analysis Tools
