About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Psen1tm1Vln
targeted mutation 1, Fred Van Leuven
MGI:2684616
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Psen1tm1Vln/Psen1tm1Vln Not Specified MGI:2684624
cn2
 		Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-cre)1Vln/0 		involves: FVB/N MGI:2684657
cn3
 		Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-cre)1Vln/0 		involves: FVB/N MGI:2684658


Genotype
MGI:2684624
hm1
Allelic
Composition		 Psen1tm1Vln/Psen1tm1Vln
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation (2 available); any Psen1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:2684657
cn2
Allelic
Composition		 Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-cre)1Vln/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation (2 available); any Psen1 mutation (61 available)
Tg(Thy1-cre)1Vln mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:87229 )
N
• mice do not display any behavioral or cognitive deficits

nervous system
nervous system phenotype ( J:87229 )
N
• brains of 6 month-old mice do not show any morphological abnormalities like cerebral hemorrhages, cavities or tumors; no defects are observed up to 2 years of age
amyloid beta deposits ( J:87229 )
• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains
abnormal long-term potentiation ( J:87229 )
• initial phase of the slope of fEPSP is lower (168% vs 221% in controls) 15 minutes after tetanic stimulation; slope of fEPSP progressively increases to approach control levels 2 hours following stimulation

homeostasis/metabolism
amyloid beta deposits ( J:87229 )
• levels of amyloid beta-40 and -42 (Abeta40, Abeta42) are reduced relative to controls; C-terminal fragments of APP accumulate in brains

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:87229
Alzheimer's disease 3 DOID:0110042 OMIM:607822
 J:87229




Genotype
MGI:2684658
cn3
Allelic
Composition		 Psen1tm1Vln/Psen1tm1Vln
Tg(Thy1-APPLon)2Vln/0
Tg(Thy1-cre)1Vln/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Vln mutation (2 available); any Psen1 mutation (61 available)
Tg(Thy1-APPLon)2Vln mutation (0 available)
Tg(Thy1-cre)1Vln mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal object recognition memory ( J:87229 )
• retention of object recognition is normal at 1 hr after training but testing of animals 3 hours after familiarization with an object reveals significant impairment relative to controls

nervous system
nervous system phenotype ( J:87229 )
N
• no thioflavin-S-reactive amyloid plaques or diffuse amyloid deposits are detected in mice up to 18 months of age
abnormal long-term potentiation ( J:87229 )
• with tetanic stimulation of hippocampal slices, after an initial slight decrease, the slope of the fEPSP approached control levels; LTP in transgenic brain slices is comparable to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory