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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Neurog3-cre/Esr1*)1Dam
transgene insertion 1, Douglas A Melton
MGI:2684324
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre/Esr1*)1Dam/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:4436917


Genotype
MGI:4436917
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Tg(Neurog3-cre/Esr1*)1Dam/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Notch1)Dam mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Neurog3-cre/Esr1*)1Dam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:86975 )
• unable to recover any viable embryos after E13.5

endocrine/exocrine glands
absent pancreatic alpha cells ( J:86975 )
• pancreas shows absence of glucagon+ alpha cells at E13.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory