Phenotypes associated with this allele

• Allele Symbol: Sp8⁺
• Allele Name: wild type
• Allele ID: MGI:2684126
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Sp8^tm1Aman/Sp8^+	involves: 129/Sv * NMRI	MGI:2684146
cx2	lgl/lgl^+ Sp8^tm1Smb/Sp8^+	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6	MGI:2684127

Genotype
MGI:2684146

ht1

• Allelic Composition: Sp8^tm1Aman/Sp8⁺
• Genetic Background: involves: 129/Sv * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal caudal vertebrae morphology ( J:86325 )

• approximately one-third of heterozygotes exhibit impaired posterior vertebra development

kinked tail ( J:86325 )

• approximately one-third of heterozygotes display a slight kink at the tip of the tail

skeleton

abnormal caudal vertebrae morphology ( J:86325 )

• approximately one-third of heterozygotes exhibit impaired posterior vertebra development

Genotype
MGI:2684127

cx2

• Allelic Composition: lgl/lgl⁺; Sp8^tm1Smb/Sp8⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

mortality/aging

perinatal lethality ( J:86196 )

• die within 24 hours of birth

craniofacial

abnormal craniofacial morphology ( J:86196 )

limbs/digits/tail

adactyly ( J:86196 )

abnormal forelimb morphology ( J:86196 )

• abnormal radius and ulna

• absence of distal bones

• normal formation of the humerus

abnormal radius morphology ( J:86196 )

• dysplastic radius

abnormal ulna morphology ( J:86196 )

• distally truncated

abnormal hindlimb morphology ( J:86196 )

• lacked structures distal to femur

absent fibula ( J:86196 )

absent tibia ( J:86196 )

abnormal tail morphology ( J:86196 )

• exhibited by 85%

caudal vertebral fusion ( J:86196 )

• fusion of tail vertebrae

skeleton

abnormal radius morphology ( J:86196 )

• dysplastic radius

abnormal ulna morphology ( J:86196 )

• distally truncated

absent fibula ( J:86196 )

absent tibia ( J:86196 )

caudal vertebral fusion ( J:86196 )

• fusion of tail vertebrae

nervous system

incomplete rostral neuropore closure ( J:86196 )

• anterior neural tube closure defects exhibited by 85% of fetuses

exencephaly ( J:86196 )

• exhibited by 59%

encephalomeningocele ( J:86196 )

• encephaloceles observed in 26%

embryo

incomplete rostral neuropore closure ( J:86196 )

• anterior neural tube closure defects exhibited by 85% of fetuses