All Phenotypes Mapk1<tm1Melo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapk1^tm1Melo
targeted mutation 1, Sylvain Meloche
MGI:2683190

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mapk1^tm1Melo/Mapk1^tm1Melo	either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * CD-1)	MGI:2683191
ht2	Mapk1^tm1Melo/Mapk1⁺	involves: 129S2/SvPas	MGI:3851932
ht3	Mapk1^tm1Melo/Mapk1⁺	involves: 129S2/SvPas * C57BL/6	MGI:2683207
ht4	Mapk1^tm1Melo/Mapk1⁺	involves: C57BL/6	MGI:3766575
cn5	Mapk1^tm1Melo/Mapk1⁺ Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0 Tg(Tek-cre)12Flv/0	involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N	MGI:3822161
cx6	Mapk1^tm1Melo/Mapk1^tm1Melo Tg(CAG-EGFP)B5Nagy/0	chimera involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * CD-1	MGI:4820405
cx7	Mapk1^tm1Melo/Mapk1⁺ Tg(Myh6-Map2k1*)1Jmol/0	involves: 129S2/SvPas * FVB	MGI:3851931
cx8	Mapk1^tm1Melo/Mapk1⁺ Tg(Myh7-Ptpn11*Q79R)11Rbns/0	involves: 129S2/SvPas * FVB/N	MGI:3822149

Allelic Composition	Mapk1^tm1Melo/Mapk1^tm1Melo
Genetic Background	either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Melo mutation (0 available); any Mapk1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:85868 )

• homozygotes die shortly after the implantation stage due to a defect in trophoblast development

• although homozygotes are obtained at normal Mendelian ratios at E6.5-E7.5, severely resorbed embryos are already detected at E8.5, indicating lethality prior to this stage

embryo

abnormal developmental patterning ( J:85868 )

• at E6.5, homozygotes display an oval shape and lack obvious proximodistal and anteroposterior polarities

abnormal proximal-distal axis patterning ( J:85868 )

• at E6.5, homozygotes show absence of obvious proximal-distal polarities

abnormal rostral-caudal axis patterning ( J:85868 )

• at E6.5, homozygotes show absence of obvious anterior-posterior polarities

decreased embryo size ( J:85868 )

• at E5.5-E7.5, homozygous mutant embryos are significantly smaller than wild-type or heterozygous embryos

abnormal polar trophectoderm morphology ( J:85868 )

• homozygotes display loss of the extra-embryonic ectoderm and ectoplacental cone, both direct derivatives of trophoblast stem cells, suggesting a primary defect at the level of polar trophectoderm

absent ectoplacental cone ( J:85868 )

• at E5.5, homozygous mutant embryos are oval in shape, with inner and outer epithelia, and lack identifiable ectoplacental cones

absent extraembryonic ectoderm ( J:85868 )

• at E6.5, homozygous mutant embryos lack an identifiable extra-embryonic ectoderm

abnormal trophoblast layer morphology ( J:85868 )

• homozygotes exhibit defective trophoblast development, probably due to abnormal proliferation of trophoblast stem cells in the polar trophectoderm

disorganized extraembryonic tissue ( J:85868 )

• at E6.5, mutant inner layers appear disorganized rather than single layers of pseudostratified epithelia as in wild-type embryos

abnormal visceral endoderm morphology ( J:85868 )

• at E5.5 and E6.5, mutant visceral endoderm cells accumulate in the proximal and distal regions of the embryos, respectively

growth/size/body

decreased embryo size ( J:85868 )

• at E5.5-E7.5, homozygous mutant embryos are significantly smaller than wild-type or heterozygous embryos

Allelic Composition	Mapk1^tm1Melo/Mapk1⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Melo mutation (0 available); any Mapk1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiac hypertrophy ( J:124903 )

• mice show significant cardiac hypertrophy comparable to wild-type following transverse aortic constriction (TAC)

decreased cardiac muscle contractility ( J:124903 )

• mice show significant reductions in fractional shortening at 4 and 8 weeks after TAC

muscle

decreased cardiac muscle contractility ( J:124903 )

• mice show significant reductions in fractional shortening at 4 and 8 weeks after TAC

growth/size/body

cardiac hypertrophy ( J:124903 )

• mice show significant cardiac hypertrophy comparable to wild-type following transverse aortic constriction (TAC)

Allelic Composition	Mapk1^tm1Melo/Mapk1⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Melo mutation (0 available); any Mapk1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:85868 )

• Background Sensitivity: fewer heterozygous pups are obtained than expected by a Mendelian ratio from heterozygous intercrosses on a background involving 129S2/SvPas and C57BL/6; in contrast, the number of heterozygous offspring is similar to what is expected on a background involving CD-1

Allelic Composition	Mapk1^tm1Melo/Mapk1⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Melo mutation (0 available); any Mapk1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased cardiac output ( J:127872 )

• after ischemia/reperfusion injury, mice show a decrease in cardiac output compared to wild-type

decreased cardiac muscle contractility ( J:127872 )

• 7 days after ischemia injury, mice have 40% more decrease in ejection fraction compared to wild-type controls and a greater decrease in dP/dtmax

increased cardiomyocyte apoptosis ( J:127872 )

• 2 fold more cardiomyocytes are undergoing apoptosis 24 hours after ischemia/reperfusion injury as compared to wild-type controls

increased myocardial infarct size ( J:127872 )

• after ischemia/reperfusion injury, mice have 30% increase in left ventricular infarct area

muscle

decreased cardiac muscle contractility ( J:127872 )

• 7 days after ischemia injury, mice have 40% more decrease in ejection fraction compared to wild-type controls and a greater decrease in dP/dtmax

increased cardiomyocyte apoptosis ( J:127872 )

• 2 fold more cardiomyocytes are undergoing apoptosis 24 hours after ischemia/reperfusion injury as compared to wild-type controls

homeostasis/metabolism

increased myocardial infarct size ( J:127872 )

• after ischemia/reperfusion injury, mice have 30% increase in left ventricular infarct area

cellular

increased cardiomyocyte apoptosis ( J:127872 )

• 2 fold more cardiomyocytes are undergoing apoptosis 24 hours after ischemia/reperfusion injury as compared to wild-type controls

Allelic Composition	Mapk1^tm1Melo/Mapk1⁺ Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0 Tg(Tek-cre)12Flv/0
Genetic Background	involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Melo mutation (0 available); any Mapk1 mutation (40 available)
Tg(CAG-cat,-Ptpn11*Q97R)1Rbns mutation (0 available)
Tg(Tek-cre)12Flv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142212 )

• all mice died by E14.5

cardiovascular system

increased atrioventricular cushion size ( J:142212 )

double outlet right ventricle ( J:142212 )

• the frequency of double outlet right ventricles is greater than in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice

ventricular septal defect ( J:142212 )

• the frequency of ventricular septal defects is greater than in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice

abnormal cardiovascular system physiology ( J:142212 )

• proliferation of endothelial, mesenchymal, and cardiomyocyte cells is increased while apoptosis rates are decreased compared to in wild-type

liver/biliary system

hepatic necrosis ( J:142212 )

homeostasis/metabolism

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

integument

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

growth/size/body

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

cellular

hepatic necrosis ( J:142212 )

Allelic Composition	Mapk1^tm1Melo/Mapk1^tm1Melo Tg(CAG-EGFP)B5Nagy/0
Genetic Background	chimera involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Melo mutation (0 available); any Mapk1 mutation (40 available)
Tg(CAG-EGFP)B5Nagy mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased fibroblast proliferation ( J:162580 )

• in mouse embryonic fibroblasts derived from tetraploid aggregation embryos

Allelic Composition	Mapk1^tm1Melo/Mapk1⁺ Tg(Myh6-Map2k1*)1Jmol/0
Genetic Background	involves: 129S2/SvPas * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Melo mutation (0 available); any Mapk1 mutation (40 available)
Tg(Myh6-Map2k1*)1Jmol mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiac hypertrophy ( J:124903 )

• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals

growth/size/body

cardiac hypertrophy ( J:124903 )

• double mutant mice show less hypertrophy at 4 weeks than Tg(Myh6-Map2k1*)1Jmol single transgenic animals

Allelic Composition	Mapk1^tm1Melo/Mapk1⁺ Tg(Myh7-Ptpn11*Q79R)11Rbns/0
Genetic Background	involves: 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Melo mutation (0 available); any Mapk1 mutation (40 available)
Tg(Myh7-Ptpn11*Q79R)11Rbns mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:123963 )

N	• unlike in Tg(Myh7-Ptpn11*Q79R)11Rbns mice, heart weight, ventricular compaction, cardiac cell proliferation and heart function are normal

respiratory system

respiratory system phenotype ( J:123963 )

N	• unlike in Tg(Myh7-Ptpn11*Q79R)11Rbns mice, lung weight is normal

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