All Phenotypes Nanos2<tm1Ysa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nanos2^tm1Ysa
targeted mutation 1, Yumiko Saga
MGI:2682606

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nanos2^tm1Ysa/Nanos2^tm1Ysa	involves: 129S1/Sv * 129X1/SvJ	MGI:3702696
hm2	Nanos2^tm1Ysa/Nanos2^tm1Ysa	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:2682626
ht3	Nanos2^tm1Ysa/Nanos2^tm3Ysa	involves: 129 * C57BL/6 * CBA * ICR	MGI:3768235
cx4	Nanos2^tm1Ysa/Nanos2^tm1Ysa Stra8^tm1Ysa/Stra8^tm1Ysa	involves: 129 * C57BL/6NCrlj * CBA/JNCrlj * Jcl:MCH(ICR)	MGI:5561053
cx5	Nanos2^tm1Ysa/Nanos2^tm1Ysa Stra8^tm1Ysa/Stra8⁺	involves: 129 * C57BL/6NCrlj * CBA/JNCrlj * Jcl:MCH(ICR)	MGI:5561055
cx6	Bax^tm1Sjk/Bax⁺ Nanos2^tm1Ysa/Nanos2^tm1Ysa	involves: 129S1/Sv * 129X1/SvJ	MGI:3778827
cx7	Bax^tm1Sjk/Bax^tm1Sjk Nanos2^tm1Ysa/Nanos2^tm1Ysa	involves: 129S1/Sv * 129X1/SvJ	MGI:3778828

Allelic Composition	Nanos2^tm1Ysa/Nanos2^tm1Ysa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nanos2^tm1Ysa mutation (0 available); any Nanos2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal gametogenesis ( J:132711 )

• male gonocytes become feminized

abnormal male germ cell morphology ( J:132711 )

• male germ cells arrest at E14.5 but unlike wild-type germ cells reinitiate proliferation from E15.5

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

cellular

abnormal male germ cell morphology ( J:132711 )

• male germ cells arrest at E14.5 but unlike wild-type germ cells reinitiate proliferation from E15.5

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

Allelic Composition	Nanos2^tm1Ysa/Nanos2^tm1Ysa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nanos2^tm1Ysa mutation (0 available); any Nanos2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased testis weight ( J:86522 )

• mutant testes were approximately 30% the weight of those of wild-type

• female gonads were morphologically and functionally normal

reproductive system

azoospermia ( J:86522 )

• ectopic and reduced numbers of germ cells were observed at E15.5

• the number of germ cells was further reduced by E18 and no germ cells were detected at 4 weeks of age

• apoptosis was observed in the testes until they were devoid of germ cells

decreased testis weight ( J:86522 )

• mutant testes were approximately 30% the weight of those of wild-type

• female gonads were morphologically and functionally normal

male infertility ( J:86522 )

• though males showed severe germ cell deficiency and were sterile, female mice were fertile

cellular

azoospermia ( J:86522 )

• ectopic and reduced numbers of germ cells were observed at E15.5

• the number of germ cells was further reduced by E18 and no germ cells were detected at 4 weeks of age

• apoptosis was observed in the testes until they were devoid of germ cells

Allelic Composition	Nanos2^tm1Ysa/Nanos2^tm3Ysa
Genetic Background	involves: 129 * C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nanos2^tm1Ysa mutation (0 available); any Nanos2 mutation (15 available)
Nanos2^tm3Ysa mutation (0 available); any Nanos2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased male germ cell number ( J:119032 )

• at E18.5, the number of male germ cells is reduced, continues to be after birth and does not recover until 5 months of age

abnormal seminiferous tubule morphology ( J:119032 )

• at 2 and 6 weeks, unlike in wild-type mice three different types of seminiferous tubule morphologies are observed, namely: ones with few spermatogonia, ones with more spermatogonia localized to the periphery and ones with few spermatocytes in addition to spermatogonia

abnormal spermatogenesis ( J:119032 )

• at E18.5, some germ cells are localized outside of the testis cord

• at E18.5 and 1 week after birth, the number of cells undergoing apoptosis in the testes is increased compared to in wild-type mice

• however, apoptosis rates in the testes are comparable to wild-type by 3 weeks of age

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:119032 )

cellular

decreased male germ cell number ( J:119032 )

• at E18.5, the number of male germ cells is reduced, continues to be after birth and does not recover until 5 months of age

Allelic Composition	Nanos2^tm1Ysa/Nanos2^tm1Ysa Stra8^tm1Ysa/Stra8^tm1Ysa
Genetic Background	involves: 129 * C57BL/6NCrlj * CBA/JNCrlj * Jcl:MCH(ICR)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nanos2^tm1Ysa mutation (0 available); any Nanos2 mutation (15 available)
Stra8^tm1Ysa mutation (0 available); any Stra8 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:205334 )

• defective

abnormal male reproductive system physiology ( J:205334 )

• male germ cells fail to maintain mitotic arrest and re-enter the cell cycle at E15.5

cellular

abnormal male meiosis ( J:205334 )

• defective

Allelic Composition	Nanos2^tm1Ysa/Nanos2^tm1Ysa Stra8^tm1Ysa/Stra8⁺
Genetic Background	involves: 129 * C57BL/6NCrlj * CBA/JNCrlj * Jcl:MCH(ICR)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male meiosis ( J:205334 )

• defective

abnormal male reproductive system physiology ( J:205334 )

• male germ cells fail to maintain mitotic arrest and re-enter the cell cycle at E15.5

cellular

abnormal male meiosis ( J:205334 )

• defective

Allelic Composition	Bax^tm1Sjk/Bax⁺ Nanos2^tm1Ysa/Nanos2^tm1Ysa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Sjk mutation (1 available); any Bax mutation (24 available)
Nanos2^tm1Ysa mutation (0 available); any Nanos2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

abnormal male germ cell apoptosis ( J:132711 )

cellular

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

abnormal male germ cell apoptosis ( J:132711 )

Allelic Composition	Bax^tm1Sjk/Bax^tm1Sjk Nanos2^tm1Ysa/Nanos2^tm1Ysa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal gametogenesis ( J:132711 )

• male gonocytes become feminized

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

• however, male germ cells do not undergo abnormal apoptosis

cellular

azoospermia ( J:132711 )

• male germ cells begin to disappear after birth and are gone by 4 weeks of age

• however, male germ cells do not undergo abnormal apoptosis

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