Phenotypes associated with this allele

• Allele Symbol: Pdgfrb^tm9Sor
• Allele Name: targeted mutation 9, Philippe Soriano
• Allele ID: MGI:2682377
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdgfrb^tm9Sor/Pdgfrb^tm9Sor	involves: 129S4/SvJae * C57BL/6	MGI:2682402
ht2	Pdgfrb^tm1Sor/Pdgfrb^tm9Sor	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:4421853

Genotype
MGI:2682402

hm1

• Allelic Composition: Pdgfrb^tm9Sor/Pdgfrb^tm9Sor
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:86542 )

• vascular defects in eyes, hearts and brains; no defects in kidney mesangial cells and pericytes in the skin and skeletal muscle

• mutants exhibit abnormalities in the vascular coating of the coronary arteries and veins

abnormal retina vasculature morphology ( J:86542 )

• decrease in vascular smooth muscle cell/pericyte population in the retina at P28

abnormal kidney vasculature morphology ( J:86542 )

• decrease in pericytes in the kidney

abnormal pericyte morphology ( J:86542 )

• 42-77% decrease in incidence of pericytes in the spinal cord, heart and kidney, compared to wild-type

• decrease in vascular smooth muscle cell/pericyte population in the retina at P28

renal/urinary system

abnormal kidney vasculature morphology ( J:86542 )

• decrease in pericytes in the kidney

vision/eye

abnormal retina vasculature morphology ( J:86542 )

• decrease in vascular smooth muscle cell/pericyte population in the retina at P28

abnormal retina layer morphology ( J:86542 )

• extensive thickening of the retinal layers

Genotype
MGI:4421853

ht2

• Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb^tm9Sor
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

cardiovascular system

abnormal blood vessel morphology ( J:86542 )

• 100% of mutants contain fewer discontinuous blood vessels and overgrowth of retinal cells, however severity of this phenotype is variable

abnormal retina vasculature morphology ( J:86542 )

• 100% of mutants contain fewer discontinuous blood vessels and overgrowth of retinal cells, however severity of this phenotype is variable

abnormal pericyte morphology ( J:86542 )

• 70-92% decrease in pericytes in the heart, kidney, and eye

• reduction in vascular smooth muscle cells/pericytes in the thoracic region of E14.5 mutants

abnormal heart morphology ( J:86542 )

• heart abnormalities

dilated heart atrium ( J:86542 )

increased heart ventricle size ( J:86542 )

cardiac fibrosis ( J:86542 )

eye hemorrhage ( J:86542 )

• sometimes exhibit hemorrhage in the eye

vision/eye

eye hemorrhage ( J:86542 )

• sometimes exhibit hemorrhage in the eye

abnormal eye morphology ( J:86542 )

• severe eye defects

abnormal retina vasculature morphology ( J:86542 )

• 100% of mutants contain fewer discontinuous blood vessels and overgrowth of retinal cells, however severity of this phenotype is variable

eye opacity ( J:86542 )