Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2tm1Kald mutation
(0 available);
any
Cdk2 mutation
(17 available)
|
|
|
reproductive system
 |
• spermatocytes with pachytene morphology and condensed sex body are rarely observed in adult males
|
liver/biliary system
|
|
• there are reduced numbers of proliferating hepatocytes 24 and 48 hours after partial hepatectomy
• there is also a slight delay in cells entering the S-phase 24 hours after partial hepatectomy
|
cellular
|
|
• spermatocytes with pachytene morphology and condensed sex body are rarely observed in adult males
|
|
|
• there are reduced numbers of proliferating hepatocytes 24 and 48 hours after partial hepatectomy
• there is also a slight delay in cells entering the S-phase 24 hours after partial hepatectomy
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2tm1Kald mutation
(0 available);
any
Cdk2 mutation
(17 available)
|
|
|
mortality/aging
|
|
• frequency of homozygous mutant mice was slightly below that expected by Mendelian ratios
• low penetrance
|
growth/size/body
|
|
• mice are slightly smaller after weaning than wild-type
|
reproductive system
 |
• oocytes do not develop in the atrophic ovaries
|
|
|
• absent primordial follicles in the ovaries
|
|
|
• small seminiferous tubules due to the large depletion of germ cells
|
|
|
• post-meiotic cells (late spermatocytes, spermatids, and spermatozoa) are absent
• however, early spermatogonia are present and Sertoli cells are normal
|
|
|
• defective differentiation of male germ cells in males as young as 3 weeks, indicating that germ cells do not enter meiosis
|
endocrine/exocrine glands
|
|
• absent primordial follicles in the ovaries
|
|
|
• small seminiferous tubules due to the large depletion of germ cells
|
cellular
|
|
• post-meiotic cells (late spermatocytes, spermatids, and spermatozoa) are absent
• however, early spermatogonia are present and Sertoli cells are normal
|
|
|
• synchronized MEFs show a delay in their entry into S phase by at least 4 hours compared to wild-type MEFs
|
|
|
• defective differentiation of male germ cells in males as young as 3 weeks, indicating that germ cells do not enter meiosis
|
|
|
• oocytes do not develop in the atrophic ovaries
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2tm1Kald mutation
(0 available);
any
Cdk2 mutation
(17 available)
Cdk4tm1Kiyo mutation
(0 available);
any
Cdk4 mutation
(57 available)
|
|
|
mortality/aging
|
|
• most, but not all, die between E14.5 and E16.5
|
cardiovascular system
|
|
• cardiomyocytes are hypertrophic and disorganized
|
|
|
• enlargement of the atria
|
|
|
• partial penetrance of an interventricular septum with a ventricular septal defect
|
|
|
• proliferation in certain areas of the heart is decreased
|
cellular
|
|
• proliferation in certain areas of the heart is decreased
|
|
|
• MEFs exhibit impaired S phase entry and premature senescence
|
|
|
• MEFs show decreased proliferation rate
|
embryo
|
|
• 80% of E14.5 and E15.5 embryos are small
|
growth/size/body
|
|
• 80% of E14.5 and E15.5 embryos are small
|
hematopoietic system
|
|
• most nucleated erythroid cells are larger than in wild-type
|
|
|
• hematopoietic cells are able to generate all progenitors and mature cells from hematopoietic stem cells, but do so to a lesser extent than wild-type due to reduced proliferation of the multipotential progenitors
|
homeostasis/metabolism
liver/biliary system
|
|
• cellularity is reduced 2.4-fold in fetal livers
|
muscle
|
|
• cardiomyocytes are hypertrophic and disorganized
|
|
|
• proliferation in certain areas of the heart is decreased
|
vision/eye
|
|
• 11% exhibit asymmetric ocular lesions
|
integument
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2tm1Kald mutation
(0 available);
any
Cdk2 mutation
(17 available)
Cdk4tm1Kiyo mutation
(0 available);
any
Cdk4 mutation
(57 available)
Cdkn1btm1Ako mutation
(0 available);
any
Cdkn1b mutation
(25 available)
|
|
|
mortality/aging
|
|
• embryos appear normal at E13.5 and die around E15.5
|
cellular
|
|
• MEFs show decreased proliferation rate
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk1tm1(Cdk2)Kald mutation
(0 available);
any
Cdk1 mutation
(21 available)
Cdk2tm1Kald mutation
(0 available);
any
Cdk2 mutation
(17 available)
|
|
|
reproductive system
|
|
• oocytes fail to develop in the atrophied ovaries of these mice
|
|
|
• there is extensive apoptosis of male germ cells in 20-day old males
|
|
|
• no follicles are observed in the ovaries of 90-day old mice
|
|
|
• ovaries of adult female mice are only half the size of controls
|
|
|
• round spermatids are absent in the testis of 20-day old males
|
|
|
• spermatocyte numbers are depleted in the testes of 3-month old mice
• there is an increase in the number of apoptotic spermatocytes in the testes of 10-day old mice
|
|
|
• a greater number of spermatocytes reach the pachytene stage of meiosis than controls
|
|
|
• the seminiferous tubules are much smaller in 3-month old males
|
|
|
• testis are 20-30% smaller than controls at twenty days of age
• testis of adult males are only half the size of controls
|
|
|
• both male and female mice are sterile
|
endocrine/exocrine glands
|
|
• no follicles are observed in the ovaries of 90-day old mice
|
|
|
• ovaries of adult female mice are only half the size of controls
|
|
|
• the seminiferous tubules are much smaller in 3-month old males
|
|
|
• testis are 20-30% smaller than controls at twenty days of age
• testis of adult males are only half the size of controls
|
cellular
|
|
• oocytes fail to develop in the atrophied ovaries of these mice
|
|
|
• round spermatids are absent in the testis of 20-day old males
|
|
|
• spermatocyte numbers are depleted in the testes of 3-month old mice
• there is an increase in the number of apoptotic spermatocytes in the testes of 10-day old mice
|
|
|
• a greater number of spermatocytes reach the pachytene stage of meiosis than controls
|
|
|
• there is extensive apoptosis of male germ cells in 20-day old males
|
Analysis Tools