Phenotypes associated with this allele
Allelic Composition |
Zfhx3Sci/Zfhx3Sci
|
|
Genetic Background |
involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfhx3Sci mutation
(2 available);
any
Zfhx3 mutation
(130 available)
|
|
|
mortality/aging
|
• lethality during embryonic development
|
Allelic Composition |
Zfhx3Sci/Zfhx3+
|
|
Genetic Background |
involves: BALB/cOlaHsd * C3H/HeH |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfhx3Sci mutation
(2 available);
any
Zfhx3 mutation
(130 available)
|
|
|
behavior/neurological
|
• circadian amplitude is reduced
• some heterozygotes display elements of free-running even with light cues and the occurrence of this phenotype is not dependent on the presence or absence of Pde6brd1
|
|
• about 50% of heterozygotes have a period less than 23 hours with the shortest period being 21.5 hours
|
|
• some heterozygotes display signs of arrhythmicity in constant darkness
|
|
• some heterozygotes display an abnormal phase angle of entrainment
|
|
• the phase delay induced by a 15 minute pulse of light at circadian time 16 hours is reduced or absent in some heterozygotes
|
|
• heterozygotes display incomplete re-entrainment when moved from constant dark back to light-dark cycles
|
Allelic Composition |
Per2tm1Jt/Per2+ Zfhx3Sci/Zfhx3+
|
|
Genetic Background |
involves: 129S6/SvEvTac * BALB/cOlaHsd * C3H/HeH * C57BL/6J |
|
|
|
nervous system
|
• the suprachiasmatic nucleus has a shorter circadian period, the period distribution is broader, and relative amplitude error (RAE) is increased in individual neurons imaged across the suprachiasmatic nucleus circuit
|