All Phenotypes Zfhx3<Sci> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zfhx3^Sci
short circuit
MGI:2679554

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfhx3^Sci/Zfhx3^Sci	involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J	MGI:5661181
ht2	Zfhx3^Sci/Zfhx3⁺	involves: BALB/cOlaHsd * C3H/HeH	MGI:2679576
cx3	Per2^tm1Jt/Per2⁺ Zfhx3^Sci/Zfhx3⁺	involves: 129S6/SvEvTac * BALB/cOlaHsd * C3H/HeH * C57BL/6J	MGI:5661032

Allelic Composition	Zfhx3^Sci/Zfhx3^Sci
Genetic Background	involves: BALB/cOlaHsd * C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfhx3^Sci mutation (2 available); any Zfhx3 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:223990 )

• lethality during embryonic development

Allelic Composition	Zfhx3^Sci/Zfhx3⁺
Genetic Background	involves: BALB/cOlaHsd * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfhx3^Sci mutation (2 available); any Zfhx3 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal circadian behavior ( J:101896 )

• circadian amplitude is reduced

• some heterozygotes display elements of free-running even with light cues and the occurrence of this phenotype is not dependent on the presence or absence of Pde6b^rd1

shortened circadian behavior period ( J:101896 )

• about 50% of heterozygotes have a period less than 23 hours with the shortest period being 21.5 hours

arrhythmic circadian behavior persistence ( J:101896 )

• some heterozygotes display signs of arrhythmicity in constant darkness

abnormal circadian behavior phase ( J:101896 )

• some heterozygotes display an abnormal phase angle of entrainment

advanced circadian behavior phase ( J:101896 )

• the phase delay induced by a 15 minute pulse of light at circadian time 16 hours is reduced or absent in some heterozygotes

abnormal circardian behavior entrainment ( J:101896 )

• heterozygotes display incomplete re-entrainment when moved from constant dark back to light-dark cycles

Allelic Composition	Per2^tm1Jt/Per2⁺ Zfhx3^Sci/Zfhx3⁺
Genetic Background	involves: 129S6/SvEvTac * BALB/cOlaHsd * C3H/HeH * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Per2^tm1Jt mutation (4 available); any Per2 mutation (73 available)
Zfhx3^Sci mutation (2 available); any Zfhx3 mutation (130 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hypothalamus physiology ( J:223990 )

• the suprachiasmatic nucleus has a shorter circadian period, the period distribution is broader, and relative amplitude error (RAE) is increased in individual neurons imaged across the suprachiasmatic nucleus circuit

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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