Zfhx3^Sci
Chemically induced Allele Detail

Summary

• Symbol: Zfhx3^Sci
• Name: zinc finger homeobox 3; short circuit
• MGI ID: MGI:2679554
• Synonyms: PLAY 8
• Gene: Zfhx3 Location: Chr8:109005975-109688268 bp, + strand Genetic Position: Chr8, 56.02 cM, cytoband E1
• Alliance: Zfhx3^Sci page

Mutation origin

• Strain of Origin: BALB/cOlaHsd

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This phenotypic mutation was identified in an ENU mutagenesis screen at the MRC Mammalian Genetics Unit, Harwell, UK. A point mutation in Zfhx3 was identified in exon 9, resulting in a G to T transversion at position 6620 and a substitution of a phenylalanine for a valine at residue 1963 (V1963F) in a highly conserved region just upstream of the 17th zinc-finger motif. This appears to be a gain of function allele. (J:223990)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Zfhx3 Mutation: 130 strains or lines available

References

• Original: J:86361 Bacon Y, et al., Screening for novel ENU-induced rhythm, entrainment and activity mutants. MGI Direct Data Submission. 2003
• All: 4 reference(s)