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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ikbkbtm1.1Cgn
targeted mutation 1.1, University of Cologne
MGI:2678816
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ikbkbtm1.1Cgn/Ikbkbtm1.1Cgn involves: C57BL/6 MGI:2679015
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Ikbkbtm1Cgn/Ikbkbtm1.1Cgn 		involves: 129P2/OlaHsd * C57BL/6 MGI:3851693
cn3
 		Ikbkbtm1Cgn/Ikbkbtm1.1Cgn
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:2679019


Genotype
MGI:2679015
hm1
Allelic
Composition		 Ikbkbtm1.1Cgn/Ikbkbtm1.1Cgn
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1.1Cgn mutation (0 available); any Ikbkb mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:85810 )
• die during embryogenesis

immune system
decreased interleukin-6 secretion ( J:79132 , J:85810 )
• TNF-mediated IL-6 production is reduced but not abolished in these embryonic cells (J:79132)
• production of IL-6 in response to IL-1, LPS, or TNF is reduced in MEFs compared to IKbkbtm2.1Cgn MEFs (J:85810)

cellular
increased fibroblast apoptosis ( J:85810 )
• mouse embryonic fibroblasts (MEFs) are more sensitive to TNF-induced apoptosis than IKbkbtm2.1Cgn MEFs




Genotype
MGI:3851693
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Ikbkbtm1Cgn/Ikbkbtm1.1Cgn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Ikbkbtm1.1Cgn mutation (0 available); any Ikbkb mutation (54 available)
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell proliferation ( J:79132 )
• B cell turnover over a one week period is almost twice that of controls
decreased immature B cell number ( J:79132 )
• immature B cell numbers in the spleen are reduced by about a half
decreased mature B cell number ( J:79132 )
• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow
• the IgMlowIgD+ mature B cell population is strongly diminished in the spleen by 3- to 4- fold
• B cell numbers in the lymph nodes are also strongly reduced
decreased B-1 B cell number ( J:79132 )
• B-1 B cell numbers are strongly decreased in the peritoneum cavity
decreased follicular B cell number ( J:79132 )
• follicular B cells are the most diminished B cell population in the spleen
decreased marginal zone B cell number ( J:79132 )
• marginal zone B cell numbers are reduced about 4-fold

hematopoietic system
increased B cell proliferation ( J:79132 )
• B cell turnover over a one week period is almost twice that of controls
decreased immature B cell number ( J:79132 )
• immature B cell numbers in the spleen are reduced by about a half
decreased mature B cell number ( J:79132 )
• there is a 2- to 4- fold reduction in the number of mature recirculating B cells found in the bone marrow
• the IgMlowIgD+ mature B cell population is strongly diminished in the spleen by 3- to 4- fold
• B cell numbers in the lymph nodes are also strongly reduced
decreased B-1 B cell number ( J:79132 )
• B-1 B cell numbers are strongly decreased in the peritoneum cavity
decreased follicular B cell number ( J:79132 )
• follicular B cells are the most diminished B cell population in the spleen
decreased marginal zone B cell number ( J:79132 )
• marginal zone B cell numbers are reduced about 4-fold

cellular
increased B cell proliferation ( J:79132 )
• B cell turnover over a one week period is almost twice that of controls




Genotype
MGI:2679019
cn3
Allelic
Composition		 Ikbkbtm1Cgn/Ikbkbtm1.1Cgn
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1.1Cgn mutation (0 available); any Ikbkb mutation (54 available)
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (54 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:85810 )
• spleen and lymph nodes are nearly devoid of T cells
decreased CD4-positive, alpha-beta T cell number ( J:85810 )
• only a mild reduction in the CD4 single-positive cells in the thymus
decreased CD8-positive, alpha-beta T cell number ( J:85810 )
• 50% reduction in CD8 single-positive cells in the thymus
decreased single-positive T cell number ( J:85810 )
• loss of single positive thymocytes during final maturation stages in the thymus

hematopoietic system
decreased T cell number ( J:85810 )
• spleen and lymph nodes are nearly devoid of T cells
decreased CD4-positive, alpha-beta T cell number ( J:85810 )
• only a mild reduction in the CD4 single-positive cells in the thymus
decreased CD8-positive, alpha-beta T cell number ( J:85810 )
• 50% reduction in CD8 single-positive cells in the thymus
decreased single-positive T cell number ( J:85810 )
• loss of single positive thymocytes during final maturation stages in the thymus




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory