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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Impdh2tm1Bmi
targeted mutation 1, Beverly S Mitchell
MGI:2678388
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Impdh2tm1Bmi/Impdh2tm1Bmi involves: 129P2/OlaHsd * C57BL/6 MGI:2678472
ht2
 		Impdh2tm1Bmi/Impdh2+ involves: 129P2/OlaHsd * C57BL/6 MGI:2678476
cx3
 		Hprt1b-m3/Y
Impdh2tm1Bmi/Impdh2+ 		involves: 129P2/OlaHsd MGI:2678480
cx4
 		Impdh1tm1Bmi/Impdh1tm1Bmi
Impdh2tm1Bmi/Impdh2+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2678464


Genotype
MGI:2678472
hm1
Allelic
Composition		 Impdh2tm1Bmi/Impdh2tm1Bmi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Impdh2tm1Bmi mutation (0 available); any Impdh2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, incomplete penetrance ( J:86045 )
• no homozygotes born
• deficient numbers of homozygotes at E3.5 (blastocysts)
• very few if any actually implant




Genotype
MGI:2678476
ht2
Allelic
Composition		 Impdh2tm1Bmi/Impdh2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Impdh2tm1Bmi mutation (0 available); any Impdh2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphocyte cell number ( J:86045 )
• proliferative response to PMA + ionomycin moderately reduced at 72 hours

hematopoietic system
abnormal lymphocyte cell number ( J:86045 )
• proliferative response to PMA + ionomycin moderately reduced at 72 hours




Genotype
MGI:2678480
cx3
Allelic
Composition		 Hprt1b-m3/Y
Impdh2tm1Bmi/Impdh2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1b-m3 mutation (4 available); any Hprt1 mutation (1274 available)
Impdh2tm1Bmi mutation (0 available); any Impdh2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphocyte cell number ( J:86045 )
• inhibited of proliferation due to anti-CD3+anti-CD28
• approximately 30% reduction of intracellular GTP when stimulated by anti-CD3 + anti-CD28
• T cells more sensitive than B cells to guanine synthesis
• greater sensitivity to MPA inhibitition of IMPDH
abnormal cytotoxic T cell physiology ( J:86045 )
• a 20-30% reduction of T cell cytolytic activity

hematopoietic system
abnormal lymphocyte cell number ( J:86045 )
• inhibited of proliferation due to anti-CD3+anti-CD28
• approximately 30% reduction of intracellular GTP when stimulated by anti-CD3 + anti-CD28
• T cells more sensitive than B cells to guanine synthesis
• greater sensitivity to MPA inhibitition of IMPDH
abnormal cytotoxic T cell physiology ( J:86045 )
• a 20-30% reduction of T cell cytolytic activity




Genotype
MGI:2678464
cx4
Allelic
Composition		 Impdh1tm1Bmi/Impdh1tm1Bmi
Impdh2tm1Bmi/Impdh2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Impdh1tm1Bmi mutation (0 available); any Impdh1 mutation (23 available)
Impdh2tm1Bmi mutation (0 available); any Impdh2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell proliferation ( J:85443 )
• decreased lymphocyte proliferation in response to anti-CD3 together with anti-Cd28
decreased splenocyte proliferation ( J:85443 )
• impairment of splenocyte proliferation also seen in response to concanavalin A, lipopolysaccharide, or to PMA + ionomycin
abnormal lymphopoiesis ( J:85443 )
• fewer cells in S phase
abnormal cytotoxic T cell physiology ( J:85443 )
• deficient T cell cytolytic effects

immune system
decreased T cell proliferation ( J:85443 )
• decreased lymphocyte proliferation in response to anti-CD3 together with anti-Cd28
decreased splenocyte proliferation ( J:85443 )
• impairment of splenocyte proliferation also seen in response to concanavalin A, lipopolysaccharide, or to PMA + ionomycin
abnormal cytotoxic T cell physiology ( J:85443 )
• deficient T cell cytolytic effects
abnormal lymphopoiesis ( J:85443 )
• fewer cells in S phase

cellular
decreased T cell proliferation ( J:85443 )
• decreased lymphocyte proliferation in response to anti-CD3 together with anti-Cd28
decreased splenocyte proliferation ( J:85443 )
• impairment of splenocyte proliferation also seen in response to concanavalin A, lipopolysaccharide, or to PMA + ionomycin




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05/07/2024
MGI 6.23 		The Jackson Laboratory