Impdh1^tm1Bmi
Targeted Allele Detail

Summary

• Symbol: Impdh1^tm1Bmi
• Name: inosine monophosphate dehydrogenase 1; targeted mutation 1, Beverly S Mitchell
• MGI ID: MGI:2678364
• Synonyms: Impdh1-, IMPDH type I^-
• Gene: Impdh1 Location: Chr6:29200435-29216363 bp, - strand Genetic Position: Chr6, 12.36 cM, cytoband A3
• Alliance: Impdh1^tm1Bmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:85443
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance gene was inserted in exon 9 together with a deletion of sequence at the end of the exon coding for amino acids 323-331. This eliminates the 2 amino acids lining the IMP binding pocket. No detectable mRNA transcripts are formed and Western blot analysis indicates that there is no gene product in thymus, lungs, or lymphocytes. (J:85443)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Impdh1 Mutation: 23 strains or lines available

References

• Original: J:85443 Gu JJ, et al., Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice. Mol Cell Biol. 2003 Sep;23(18):6702-12
• All: 4 reference(s)