All Phenotypes Impdh1<tm1Bmi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Impdh1^tm1Bmi
targeted mutation 1, Beverly S Mitchell
MGI:2678364

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Impdh1^tm1Bmi/Impdh1^tm1Bmi	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2678462
cx2	Impdh1^tm1Bmi/Impdh1^tm1Bmi Impdh2^tm1Bmi/Impdh2⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2678464
cx3	Hprt1^b-m3/Y Impdh1^tm1Bmi/Impdh1^tm1Bmi	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2678469

Allelic Composition	Impdh1^tm1Bmi/Impdh1^tm1Bmi
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Impdh1^tm1Bmi mutation (0 available); any Impdh1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:85443 )

• decreased lymphocyte proliferation in response to anti-CD3 together with anti-CD28

abnormal immune system cell morphology ( J:85443 )

hematopoietic system

decreased T cell proliferation ( J:85443 )

• decreased lymphocyte proliferation in response to anti-CD3 together with anti-CD28

cellular

decreased T cell proliferation ( J:85443 )

• decreased lymphocyte proliferation in response to anti-CD3 together with anti-CD28

Allelic Composition	Impdh1^tm1Bmi/Impdh1^tm1Bmi Impdh2^tm1Bmi/Impdh2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Impdh1^tm1Bmi mutation (0 available); any Impdh1 mutation (23 available)
Impdh2^tm1Bmi mutation (0 available); any Impdh2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T cell proliferation ( J:85443 )

• decreased lymphocyte proliferation in response to anti-CD3 together with anti-Cd28

decreased splenocyte proliferation ( J:85443 )

• impairment of splenocyte proliferation also seen in response to concanavalin A, lipopolysaccharide, or to PMA + ionomycin

abnormal lymphopoiesis ( J:85443 )

• fewer cells in S phase

abnormal cytotoxic T cell physiology ( J:85443 )

• deficient T cell cytolytic effects

immune system

decreased T cell proliferation ( J:85443 )

• decreased lymphocyte proliferation in response to anti-CD3 together with anti-Cd28

decreased splenocyte proliferation ( J:85443 )

• impairment of splenocyte proliferation also seen in response to concanavalin A, lipopolysaccharide, or to PMA + ionomycin

abnormal cytotoxic T cell physiology ( J:85443 )

• deficient T cell cytolytic effects

abnormal immune system cell morphology ( J:85443 )

abnormal lymphopoiesis ( J:85443 )

• fewer cells in S phase

cellular

decreased T cell proliferation ( J:85443 )

• decreased lymphocyte proliferation in response to anti-CD3 together with anti-Cd28

decreased splenocyte proliferation ( J:85443 )

• impairment of splenocyte proliferation also seen in response to concanavalin A, lipopolysaccharide, or to PMA + ionomycin

Allelic Composition	Hprt1^b-m3/Y Impdh1^tm1Bmi/Impdh1^tm1Bmi
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^b-m3 mutation (4 available); any Hprt1 mutation (1274 available)
Impdh1^tm1Bmi mutation (0 available); any Impdh1 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased T cell proliferation ( J:85443 )

• decreased lymphocyte proliferation due to anti-CD3 + anti-CD28

decreased splenocyte proliferation ( J:85443 )

• impaired splenocyte proliferation in response to concanavalin A, lipopolysaccharide, or to PMA + ionomycin

abnormal lymphopoiesis ( J:85443 )

• light but significant drop in proportion of T cells

• fewer cells in S phase

decreased cytotoxic T cell cytolysis ( J:85443 )

• deficient T cell cytolytic effect

immune system

decreased T cell proliferation ( J:85443 )

• decreased lymphocyte proliferation due to anti-CD3 + anti-CD28

decreased splenocyte proliferation ( J:85443 )

• impaired splenocyte proliferation in response to concanavalin A, lipopolysaccharide, or to PMA + ionomycin

abnormal lymphopoiesis ( J:85443 )

• light but significant drop in proportion of T cells

• fewer cells in S phase

decreased cytotoxic T cell cytolysis ( J:85443 )

• deficient T cell cytolytic effect

decreased interleukin-4 secretion ( J:85443 )

• decreased secretion of Il-4 due to decreased GTP levels

• Il-2 levels remain more or less normal

cellular

decreased T cell proliferation ( J:85443 )

• decreased lymphocyte proliferation due to anti-CD3 + anti-CD28

decreased splenocyte proliferation ( J:85443 )

• impaired splenocyte proliferation in response to concanavalin A, lipopolysaccharide, or to PMA + ionomycin

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