Phenotypes associated with this allele

• Allele Symbol: Hba⁺
• Allele Name: wild type
• Allele ID: MGI:2677906
• Summary: 15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hba^th-J/Hba^+	B6.Cg-Hba^th-J	MGI:4355965
ht2	Hba^b2(th)/Hba^+	either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)	MGI:3720079
ht3	Hba^b3(th)/Hba^+	either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)	MGI:3720086
ht4	Hba^b2(th)/Hba^+	involves: 101/Rl * SEC/Rl	MGI:3720078
ht5	Hba^b3(th)/Hba^+	involves: 101 * SEC	MGI:3720085
ht6	Rhbdf1/Hba^tm2Ajhs/Hba^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5309165
ht7	Rhbdf1/Hba^tm2.1Ajhs/Hba^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5309167
ht8	Rhbdf1/Hba^tm1(RHBDF1/HBA)Ajhs/Hba^+	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5309158
ht9	Hba^tm1Paz/Hba^+	involves: 129S7/SvEvBrd	MGI:5309169
ht10	Hba^th-J/Hba^+	involves: C57BL/6J	MGI:2450518
ht11	Hba^b3(th)/Hba^+	involves: C57BL/6J * SEC	MGI:3720087
ht12	Hba^b2(th)/Hba^+	involves: C57BL/6J * SEC	MGI:3720080
ht13	Hba^b2(th)/Hba^+	SEC-Hba^b2(th)	MGI:3720082
ht14	Hba^b3(th)/Hba^+	SEC-Hba^b3(th)	MGI:3720088
cx15	Hba^tm1Paz/Hba^+ Hbb^tm1Tow/Hbb^tm1Tow	involves: 129S2/SvPas * 129S7/SvEvBrd	MGI:5529820

Genotype
MGI:4355965

ht1

• Allelic Composition: Hba^th-J/Hba⁺
• Genetic Background: B6.Cg-Hba^th-J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

maternal effect ( J:29127 )

• offspring of heterozygous females, both wild-type and heterozygous offspring, have lower body weights than the offspring of wild-type mothers bred to heterozygous males

Genotype
MGI:3720079

ht2

• Allelic Composition: Hba^b2(th)/Hba⁺
• Genetic Background: either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)

hematopoietic system

hypochromic microcytic anemia ( J:123943 )

increased erythrocyte cell number ( J:123943 )

decreased hematocrit ( J:123943 )

decreased hemoglobin content ( J:123943 )

decreased mean corpuscular hemoglobin ( J:123943 )

decreased mean corpuscular volume ( J:123943 )

• reduced mean cell volume despite increased red cell numbers

anisocytosis ( J:123943 )

acanthocytosis ( J:86011 )

anisopoikilocytosis ( J:86011 )

• red cells of irregular size and shape with pitted surfaces and blebs are seen

dacryocytosis ( J:86011 )

leptocytosis ( J:86011 )

• increase in the percentage of red blood cells with flattened or doughnut shape (26%) compared to controls

microcytosis ( J:123943 )

• red cells are 75 - 80% the size of wild-type cells

poikilocytosis ( J:86011 )

• increase in the percentage of acanthocytes and red blood cells with teardrop shape (43.2%) compared to controls

increased leukocyte cell number ( J:123943 )

• Background Sensitivity: white cell numbers are increased in mice crossed to C57BL mice but not in those crossed to SEC mice

reticulocytosis ( J:123943 )

immune system

increased leukocyte cell number ( J:123943 )

• Background Sensitivity: white cell numbers are increased in mice crossed to C57BL mice but not in those crossed to SEC mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:123943

Genotype
MGI:3720086

ht3

• Allelic Composition: Hba^b3(th)/Hba⁺
• Genetic Background: either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)

hematopoietic system

hypochromic microcytic anemia ( J:123943 )

increased erythrocyte cell number ( J:123943 )

decreased hematocrit ( J:123943 )

decreased hemoglobin content ( J:123943 )

decreased mean corpuscular hemoglobin ( J:123943 )

decreased mean corpuscular volume ( J:123943 )

• reduced mean cell volume despite increased red cell numbers

anisocytosis ( J:123943 )

acanthocytosis ( J:86011 )

anisopoikilocytosis ( J:86011 )

• red cells of irregular size and shape with pitted surfaces and blebs are seen

dacryocytosis ( J:86011 )

leptocytosis ( J:86011 )

• increase in the percentage of cells with flattened or doughnut (34.5%) shape compared to controls

microcytosis ( J:123943 )

• red cells are 75 - 80% the size of wild-type cells

poikilocytosis ( J:86011 )

• increase in the percentage of acanthocytes or cells with teardrop shape (6.2%) compared to controls

reticulocytosis ( J:123943 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:123943

Genotype
MGI:3720078

ht4

• Allelic Composition: Hba^b2(th)/Hba⁺
• Genetic Background: involves: 101/Rl * SEC/Rl

hematopoietic system

abnormal hemoglobin ( J:5686 )

• display a diminished fast band, higher than normal solubility, and precipitates containing few, large, found aggregates of crystals

increased erythrocyte clearance ( J:150481 )

• chromium labelled erythrocytes transplanted from heterozygous males into wild-type hosts have a half-life of only 10.3 days whereas that from normal donors into normal hosts is 12.7 days

• the calculated lifespan of transplanted heterozygous erythrocytes is shorter than of transplanted normal erythrocytes

mortality/aging

premature death ( J:150481 )

• the mean age of death is less than normal

Genotype
MGI:3720085

ht5

• Allelic Composition: Hba^b3(th)/Hba⁺
• Genetic Background: involves: 101 * SEC

hematopoietic system

abnormal hemoglobin ( J:5686 )

• display a diminished fast band, higher than normal solubility, and precipitates containing few, large, found aggregates of crystals

Genotype
MGI:5309165

ht6

• Allelic Composition: Rhbdf1/Hba^tm2Ajhs/Hba⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

hematopoietic system

decreased hemoglobin content ( J:117887 )

decreased mean corpuscular hemoglobin ( J:117887 )

decreased mean corpuscular volume ( J:117887 )

anisopoikilocytosis ( J:117887 )

microcytosis ( J:117887 )

Genotype
MGI:5309167

ht7

• Allelic Composition: Rhbdf1/Hba^tm2.1Ajhs/Hba⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

hematopoietic system

decreased hemoglobin content ( J:117887 )

decreased mean corpuscular hemoglobin ( J:117887 )

decreased mean corpuscular volume ( J:117887 )

Genotype
MGI:5309158

ht8

• Allelic Composition: Rhbdf1/Hba^{tm1(RHBDF1/HBA)Ajhs}/Hba⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

hematopoietic system

anisopoikilocytosis ( J:117887 )

• minor

Genotype
MGI:5309169

ht9

• Allelic Composition: Hba^tm1Paz/Hba⁺
• Genetic Background: involves: 129S7/SvEvBrd

hematopoietic system

decreased hemoglobin content ( J:117887 )

decreased mean corpuscular hemoglobin ( J:117887 )

decreased mean corpuscular volume ( J:117887 )

reticulocytosis ( J:117887 )

Genotype
MGI:2450518

ht10

• Allelic Composition: Hba^th-J/Hba⁺
• Genetic Background: involves: C57BL/6J

mortality/aging

postnatal lethality ( J:32654 )

• fewer than expected heterozygous mice are found at weaning (39% compared to the expected 50%)

growth/size/body

decreased body weight ( J:45721 )

hematopoietic system

increased erythrocyte cell number ( J:45721 )

• erythrocytosis

decreased hemoglobin content ( J:45721 )

• low blood hemoglobin levels

microcytosis ( J:45721 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:32654 , J:45721

Genotype
MGI:3720087

ht11

• Allelic Composition: Hba^b3(th)/Hba⁺
• Genetic Background: involves: C57BL/6J * SEC

mortality/aging

postnatal lethality ( J:32654 )

• fewer than expected heterozygous mice are found at weaning (9% compared to the expected 50%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:32654

Genotype
MGI:3720080

ht12

• Allelic Composition: Hba^b2(th)/Hba⁺
• Genetic Background: involves: C57BL/6J * SEC

mortality/aging

postnatal lethality ( J:32654 )

• fewer than expected heterozygous mice are found at weaning (37% compared to the expected 50%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:32654

Genotype
MGI:3720082

ht13

• Allelic Composition: Hba^b2(th)/Hba⁺
• Genetic Background: SEC-Hba^b2(th)

hematopoietic system

abnormal fetal derived definitive erythrocyte morphology ( J:6452 )

• at E13.5 - E15.5, eosinophilic inclusions are seen in liver derived erythrocytes

• however, no abnormalities are seen in yolk-sac derived nucleated erythrocytes

growth/size/body

growth/size/body region phenotype ( J:6452 )

N • unlike mice heterozygous for SEC-Hba^b3(th), body weights of heterozygous mice are similar to control littermates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:6452

Genotype
MGI:3720088

ht14

• Allelic Composition: Hba^b3(th)/Hba⁺
• Genetic Background: SEC-Hba^b3(th)

mortality/aging

postnatal lethality, incomplete penetrance ( J:6452 )

• many pups die between birth and weaning

hematopoietic system

abnormal fetal derived definitive erythrocyte morphology ( J:6452 )

• at E13.5 - E15.5, eosinophilic inclusions are seen in liver derived erythrocytes

• however, no abnormalities are seen in yolk-sac derived nucleated erythrocytes

growth/size/body

decreased birth body size ( J:6452 )

• newborn pups are smaller than wild-type littermates

decreased body weight ( J:6452 )

• reduced in heterozygous adults to 18.77 +/- 0.59g compared to 23.79 +/- 0.39g in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alpha thalassemia		DOID:1099	OMIM:604131	J:6452

Genotype
MGI:5529820

cx15

• Allelic Composition: Hba^tm1Paz/Hba⁺; Hbb^tm1Tow/Hbb^tm1Tow
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

hematopoietic system

abnormal erythroid progenitor cell morphology ( J:204029 )

• a small population of Ter119+ CD71^low fetal liver cells unlike in wild-type mice

decreased erythroid progenitor cell number ( J:204029 )

• greater impairment of Ter119+ CD71^hi cells than in double homozygotes