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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hif1atm1Stom
targeted mutation 1, Shuhei Tomita
MGI:2677892
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Hif1atm1Stom/Hif1atm1Stom
Tg(Vil1-cre)20Syr/0
B6.Cg-Hif1atm1Stom Tg(Vil1-cre)20Syr MGI:7310211
cn2
Hif1atm1Stom/Hif1atm1Stom
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: FVB/N MGI:3815316
cn3
Hif1atm1Stom/Hif1atm1.1Stom
Tg(Nes-cre)1Kag/0
Not Specified MGI:3815314


Genotype
MGI:7310211
cn1
Allelic
Composition
Hif1atm1Stom/Hif1atm1Stom
Tg(Vil1-cre)20Syr/0
Genetic
Background
B6.Cg-Hif1atm1Stom Tg(Vil1-cre)20Syr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1atm1Stom mutation (0 available); any Hif1a mutation (48 available)
Tg(Vil1-cre)20Syr mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• higher rectal temperature after cold challenge in mice fed a high-fat diet following a more significant drop in inguinal region
• however, response to is restored following oral or rectal administration of lactate
• in fasted mice fed a high-fat diet
• after cold challenge in mice fed a high-fat diet
• however, treatment with lactate restores normal energy expenditure
• despite equivalent food intake, mice fed a high-fat diet exhibit improved body weight gain and body fat content compared with control mice
• in the inguinal fat and epididymal fat of mice fed a high-fat diet after cold challenge along with increased mitochondrial CK activity
• however, treatment with lactate restores normal adaptive thermogenesis
• after cold challenge in mice fed a high-fat diet
• however, treatment with lactate restores normal RER
• in mice fed a high-fat diet
• in mice fed a high-fat diet
• especially conjugated bile acids TCA and tauro-beta-muricholic acid, and precursor DCA in mice fed a high-fat diet compared with control mice

digestive/alimentary system
• mice fed a high-fat diet exhibit inhibition of B. vulgatus and enrichment of R. torques associated with reduction in intestinal lactate levels compared with control mice

adipose tissue
• in mice fed a high-fat diet

growth/size/body
• in mice fed a high-fat diet
• despite equivalent food intake, mice fed a high-fat diet exhibit improved body weight gain and body fat content compared with control mice




Genotype
MGI:3815316
cn2
Allelic
Composition
Hif1atm1Stom/Hif1atm1Stom
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (39 available)
Hif1atm1Stom mutation (0 available); any Hif1a mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• reduced number of microvessels form 2 weeks after transverse aortic constriction
• attenuated development of hypertrophy as a result of transverse aortic restriction
• impaired cardiac function




Genotype
MGI:3815314
cn3
Allelic
Composition
Hif1atm1Stom/Hif1atm1.1Stom
Tg(Nes-cre)1Kag/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1atm1.1Stom mutation (0 available); any Hif1a mutation (48 available)
Hif1atm1Stom mutation (0 available); any Hif1a mutation (48 available)
Tg(Nes-cre)1Kag mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• density of blood vessels is reduced
• in adults
• thinner than in controls at E19
• dense nuclei found with a wavy architecture
• apoptotic neural and glial cells detected
• atrophy of the cerebral cortex in adults
• significant reduction of neurons at 10 weeks of age although six layered structure of the cortex is maintained
• 36% reduction of neurons at 10 weeks of age
• 36% loss of neurons in the perirhinal cortex at 10 weeks of age
• 12% reduction of neurons on the dorsal side

behavior/neurological
N
• spontaneous activity is normal
• significantly impaired memory consolidation after 4 days of testing using a radial maze task





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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory