All Phenotypes Ccne2<tm1Boa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ccne2^tm1Boa
targeted mutation 1, Bruno Amati
MGI:2677700

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccne2^tm1Boa/Ccne2^tm1Boa	involves: 129/Sv * C57BL/6	MGI:2677715
cx2	Ccne1^tm1Pisc/Ccne1^tm1Pisc Ccne2^tm1Boa/Ccne2^tm1Boa	involves: 129/Sv * C57BL/6	MGI:2677716

Allelic Composition	Ccne2^tm1Boa/Ccne2^tm1Boa
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne2^tm1Boa mutation (0 available); any Ccne2 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

small testis ( J:85497 )

• at 2 months of age the testis is 2/3 normal size

reproductive system

abnormal reproductive system morphology ( J:85497 )

oligozoospermia ( J:85497 )

• 25-70% reduction in mature spermatozoa

small testis ( J:85497 )

• at 2 months of age the testis is 2/3 normal size

abnormal fertility/fecundity ( J:85497 )

reduced male fertility ( J:85497 )

cellular

oligozoospermia ( J:85497 )

• 25-70% reduction in mature spermatozoa

Allelic Composition	Ccne1^tm1Pisc/Ccne1^tm1Pisc Ccne2^tm1Boa/Ccne2^tm1Boa
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1^tm1Pisc mutation (0 available); any Ccne1 mutation (23 available)
Ccne2^tm1Boa mutation (0 available); any Ccne2 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:85497 )

• most are dead at E11.5

• 2 of 10 still had beating hearts at E11.5

• most double homozygotes were still alive at E10.5

cardiovascular system

abnormal vasculogenesis ( J:85497 )

• cranial vascularization at E10.5 like that typical at E9.5

abnormal vitelline vasculature morphology ( J:85497 )

• 60% showing poorly vascularized yolk sac at E11.5

embryo

embryonic growth retardation ( J:85497 )

abnormal extraembryonic tissue morphology ( J:85497 )

abnormal vitelline vasculature morphology ( J:85497 )

• 60% showing poorly vascularized yolk sac at E11.5

abnormal trophoblast layer morphology ( J:85497 )

• reduced DNA content in trophoblast giant cells

• failure of endoreplication, few cells reach a ploidy of 8N

growth/size/body

abnormal embryonic growth/weight/body size ( J:85497 )

• no obvious morphological defects at E9.5-11.5

embryonic growth retardation ( J:85497 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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