All Phenotypes Hba-x<tm1Led> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hba-x^tm1Led
targeted mutation 1, Philip Leder
MGI:2677497

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hba-x^tm1Led/Hba-x^tm1Led	involves: 129S6/SvEvTac	MGI:2679490
hm2	Hba-x^tm1Led/Hba-x^tm1Led	involves: 129S6/SvEvTac * NIH Black Swiss	MGI:2679493
ht3	Hba-x^tm1Led/Hba-x⁺	involves: 129S6/SvEvTac * NIH Black Swiss	MGI:2679492
cx4	Hba-a1^tm1Led/Hba-a1⁺ Hba-x^tm1Led/Hba-x⁺	involves: 129S6/SvEvTac * NIH Black Swiss	MGI:2679489

Allelic Composition	Hba-x^tm1Led/Hba-x^tm1Led
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba-x^tm1Led mutation (1 available); any Hba-x mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:41934 )

• all animals die before birth

Allelic Composition	Hba-x^tm1Led/Hba-x^tm1Led
Genetic Background	involves: 129S6/SvEvTac * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba-x^tm1Led mutation (1 available); any Hba-x mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:41934 )

• variable penetrance; some animals die before birth while a few others survive to adulthood

growth/size/body

postnatal growth retardation ( J:41934 )

• variable penetrance; some animals appear runted or smaller than littermates, while others appear normal

hematopoietic system

anemia ( J:41934 )

• variable penetrance

abnormal erythrocyte morphology ( J:41934 )

abnormal hemoglobin ( J:41934 )

• reduced hemoglobin concentration

abnormal mean corpuscular hemoglobin ( J:41934 )

abnormal mean corpuscular volume ( J:41934 )

anisocytosis ( J:41934 )

poikilocytosis ( J:41934 )

polychromatophilia ( J:41934 )

thrombocytosis ( J:41934 )

reproductive system

decreased litter size ( J:41934 )

Allelic Composition	Hba-x^tm1Led/Hba-x⁺
Genetic Background	involves: 129S6/SvEvTac * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba-x^tm1Led mutation (1 available); any Hba-x mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal hemoglobin ( J:41934 )

• reduced hemoglobin concentration

abnormal mean corpuscular hemoglobin ( J:41934 )

abnormal mean corpuscular volume ( J:41934 )

Allelic Composition	Hba-a1^tm1Led/Hba-a1⁺ Hba-x^tm1Led/Hba-x⁺
Genetic Background	involves: 129S6/SvEvTac * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hba-a1^tm1Led mutation (1 available); any Hba-a1 mutation (5 available)
Hba-x^tm1Led mutation (1 available); any Hba-x mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal hemoglobin ( J:41934 )

• reduced hemoglobin concentration

abnormal mean corpuscular hemoglobin ( J:41934 )

abnormal mean corpuscular volume ( J:41934 )

thrombocytosis ( J:41934 )

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