About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ephb1tm2Cmn
targeted mutation 2, Carol A Mason
MGI:2677312
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ephb1tm2Cmn/Ephb1tm2Cmn involves: 129S1/Sv * 129X1/SvJ MGI:8228062
ht2
 		Ephb1tm1Cmn/Ephb1tm2Cmn involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:2677322
cx3
 		Ephb1tm2Cmn/Ephb1tm2Cmn
Lnx1tm1Henk/Lnx1tm1Henk 		involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:8228080


Genotype
MGI:8228062
hm1
Allelic
Composition		 Ephb1tm2Cmn/Ephb1tm2Cmn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm2Cmn mutation (0 available); any Ephb1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:267455 )
N
• unlike in mice homozygous for Ephb1tm1Cmn no obvious change in the length of the infrapyramidal bundle is seen




Genotype
MGI:2677322
ht2
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm2Cmn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (45 available)
Ephb1tm2Cmn mutation (0 available); any Ephb1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye morphology ( J:85573 )
• express beta-gal in cells normally expressing Ephb1
abnormal optic nerve innervation ( J:85573 )
• embryos demonstrate misprojection of axons contralaterally

nervous system
abnormal optic nerve innervation ( J:85573 )
• embryos demonstrate misprojection of axons contralaterally




Genotype
MGI:8228080
cx3
Allelic
Composition		 Ephb1tm2Cmn/Ephb1tm2Cmn
Lnx1tm1Henk/Lnx1tm1Henk
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm2Cmn mutation (0 available); any Ephb1 mutation (45 available)
Lnx1tm1Henk mutation (0 available); any Lnx1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampal mossy fiber morphology ( J:267455 )
• mossy fiber defects are similar to mice null for Lnx1 alone




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory