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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ephb1tm2Cmn
targeted mutation 2, Carol A Mason
MGI:2677312
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ephb1tm2Cmn/Ephb1tm2Cmn involves: 129S1/Sv * 129X1/SvJ MGI:8228062
ht2
 		Ephb1tm1Cmn/Ephb1tm2Cmn involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:2677322
cx3
 		Ephb1tm2Cmn/Ephb1tm2Cmn
Lnx1tm1Henk/Lnx1tm1Henk 		involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:8228080


Genotype
MGI:8228062
hm1
Allelic
Composition		 Ephb1tm2Cmn/Ephb1tm2Cmn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm2Cmn mutation (0 available); any Ephb1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:267455 )
N
• unlike in mice homozygous for Ephb1tm1Cmn no obvious change in the length of the infrapyramidal bundle is seen




Genotype
MGI:2677322
ht2
Allelic
Composition		 Ephb1tm1Cmn/Ephb1tm2Cmn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Cmn mutation (1 available); any Ephb1 mutation (44 available)
Ephb1tm2Cmn mutation (0 available); any Ephb1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye morphology ( J:85573 )
• express beta-gal in cells normally expressing Ephb1
abnormal optic nerve innervation ( J:85573 )
• embryos demonstrate misprojection of axons contralaterally

nervous system
abnormal optic nerve innervation ( J:85573 )
• embryos demonstrate misprojection of axons contralaterally




Genotype
MGI:8228080
cx3
Allelic
Composition		 Ephb1tm2Cmn/Ephb1tm2Cmn
Lnx1tm1Henk/Lnx1tm1Henk
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm2Cmn mutation (0 available); any Ephb1 mutation (44 available)
Lnx1tm1Henk mutation (0 available); any Lnx1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampal mossy fiber morphology ( J:267455 )
• mossy fiber defects are similar to mice null for Lnx1 alone




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory