Analysis Tools
embryo
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• placenta size is 67% of normal at E18.5
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growth/size/body
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• birth weight is 61.5% of normal
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Allele Symbol Allele Name Allele ID |
Igf2tm1Rob targeted mutation 1, Elizabeth J Robertson MGI:2677156 |
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| Summary |
45 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• placenta size is 67% of normal at E18.5
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• birth weight is 61.5% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 40% reduction in body weight relative to wild-type littermates but only when the mutated allele is inherited paternally
(J:10453)
• the rate of postnatal growth was similar to that of wild-type
(J:10453)
• viable dwarfs with body weight 60% of normal when the mutated allele is inherited paternally
(J:15108)
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• when the mutated allele is inherited paternally, mutants exhibit a one day developmental delay in hyoid, cervical, and lumbar vertebrae, radius, ulna, femur, digits, nasal bone, and all cranial bones, except for the frontal and temporal bones
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only when the mutated allele is inherited paternally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• but only when the mutated allele is inherited paternally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some mice die between E14.5 and E18.5
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• when Igf2tm1Rob is inherited maternally, mice do not survive postnatally
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• when Igf2tm1Rob is inherited maternally, the muscular wall of the heart is hyperplastic and hyperplastic endothelial cells accumulate in the intertrabecular spaces of the ventricles unlike in wild-type mice
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• when Igf2tm1Rob is inherited maternally, sinusoids are observed in the septa unlike in wild-type mice
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• when Igf2tm1Rob is inherited maternally
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• when Igf2tm1Rob is inherited maternally, the number of sinusoids in the ventricles is increased compared to in wild-type mice
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• when Igf2tm1Rob is inherited maternally, heart cell proliferation atE13.5 is increased compared to in wild-type mice
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• when Igf2tm1Rob is inherited maternally, minor lens abnormalities are observed
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• when Igf2tm1Rob is inherited maternally, 5 of 14 mice have open eyelids at E16.5
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• when Igf2tm1Rob is inherited maternally, placenta weight is 140% of wild-type mice at E15.5
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• when Igf2tm1Rob is inherited maternally, 1 of 3 mice develops a few small cysts
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• when Igf2tm1Rob is inherited maternally
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• when Igf2tm1Rob is inherited maternally, 1 of 3 mice develops a few small cysts
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• when Igf2tm1Rob is inherited maternally, 7 to 22 mice exhibit mild omphalocele consisting of a protrusion of only a small portion of the liver or of a mild herniation of only the gut
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• when Igf2tm1Rob is inherited maternally, mice weight 140% of normal at E18.5
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• when Igf2tm1Rob is inherited maternally
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• when Igf2tm1Rob is inherited maternally, serum insulin-like growth factor II levels are increase compared to in wild-type mice
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• when Igf2tm1Rob is inherited maternally, penetrance of type A and B postaxial polydactyly is incomplete with either a small extra digit that contains a single phalangeal bone or an extra digits with two phalanges
• when Igf2tm1Rob is inherited maternally, a minority of mice exhibit preaxial polydactyly with doubling or bifurcation of the distal phalanx of the pollex associated with postaxial polydactyly
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• when Igf2tm1Rob is inherited maternally
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• when Igf2tm1Rob is inherited maternally
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• when Igf2tm1Rob is inherited maternally, heart cell proliferation atE13.5 is increased compared to in wild-type mice
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• when Igf2tm1Rob is inherited maternally, the ossification centers of the fourth sternebra are not fused along the midline and are underdeveloped compared to in wild-type mice at E17.5
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• when Igf2tm1Rob is inherited maternally, the xiphisternum has unfused centers and is very broad compared to in wild-type mice
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• when Igf2tm1Rob is inherited maternally, the twin ossification centers in L3 are fused at E16.5
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• when Igf2tm1Rob is inherited maternally
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• when Igf2tm1Rob is inherited maternally, heart cell proliferation atE13.5 is increased compared to in wild-type mice
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• when Igf2tm1Rob is inherited maternally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• but only when the mutated allele is inherited paternally
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|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5
• however, when this allele is inherited maternally mice exhibit normal placenta weight
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• when Igf2tm1Rob is inherited paternally, birth weight is 61.5% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis of mRNA extracted from 8-10 pooled, whole 12.5-17.5 days post coitus (dpc) embryos with a nonfunctional paternal Igf2 allele demonstrates that those with a repressor binding site-disrupted maternal Igf2 allele express approximately 3-fold the amount of Igf2 mRNA as embryos with a normally repressed wild-type maternal allele; this is confirmed by RNAse protection analysis.
• while whole-embryo results primarily reflect expression in the mesoderm, analysis of placenta, yolk sac and endoderm-derived tissues including liver produces similar results.
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| N |
• unlike pups that inherit an Igf2 allele whose repressor binding site is disrupted by the floxed neor cassette, pups with the present, loxP-only disruption do not differ in size from their littermates.
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double mutants with a paternally inherited Igf2 allele die shortly after birth of respiratory failure
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• birth weight is about 30% of wild-type in double mutants with a paternally inherited Igf2 allele
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• double mutants with a paternally inherited Igf2 allele exhibit the same developmental delays in the ossification of particular bones as the Igf1rtm1Arge single mutants
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• defects are seen in double mutants with a paternally inherited Igf2 allele
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• the stratum spinosum is underdeveloped in double mutants with a paternally inherited Igf2 allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• double mutants with a paternally inherited Igf2 allele die immediately after birth of respiratory failure
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• birth weight is about 30% of wild-type in double mutants with a paternally inherited Igf2 allele
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• the central nervous system of double mutants with a paternally inherited Igf2 allele exhibits the same high cellular density seen in Igf1r single mutants
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• delays in bone development are somewhat more pronounced in double mutants with a paternally inherited Igf2 allele than in Igf1r single mutants
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• defects are seen in double mutants with a paternally inherited Igf2 allele
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• double mutants with a paternally inherited Igf2 allele exhibit an underdeveloped epidermis similar to that seen in Igf1r single mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• indistinguishable in size from wild-type in birth weights and postnatal growth rates
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when each allele is inherited maternally, mice begin to die at E14.5 and are all dead by E18.5
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• when each allele is inherited maternally or when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally, the muscular wall of the heart is hyperplastic and hyperplastic endothelial cells accumulate in the intertrabecular spaces of the ventricles and atria unlike in wild-type mice
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• when each allele is inherited maternally, sinusoids are observed in the septa unlike in wild-type mice
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• when each allele is inherited maternally
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• when each allele is inherited maternally, the number of sinusoids in the ventricles is increased compared to in wild-type mice
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• when each allele is inherited maternally, the aortic valve is large and thickened compared to in wild-type mice
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• when each allele is inherited maternally, the pulmonary valve is large and thickened compared to in wild-type mice
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• when each allele is inherited maternally, 2 of 4 mice exhibit accumulation of pericardial fluid unlike in wild-type mice
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• when each allele is inherited maternally or when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally, heart cell proliferation at E13.5 is increased compared to in wild-type mice
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• when each allele is inherited maternally, the anterior surface of the lens fiber cell fails to make contact with the interior surface of the lens epithelium at E13.5 to E17.5 leaving a position of the lumen unfilled unlike in wild-type mice
• when each allele is inherited maternally, severely affected mice exhibit abnormal suturing patterns
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• poorly organized when each allele is inherited maternally
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• when each allele is inherited maternally, 12 of 13 mice have open eyelids at E16.5 and E17.5
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• when each allele is inherited maternally or when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally
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• when each allele is inherited maternally or when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally
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• when each allele is inherited maternally, penetrance of type B-like postaxial polydactyly is complete with a small extra digit that contains a single phalangeal bone
• when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally, penetrance of type A and B postaxial polydactyly is incomplete with either a small extra digit that contains a single phalangeal bone, an extra digits with two phalanges, or an extra digit with a third skeletal element
• when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally, a minority of mice exhibit preaxial polydactyly with doubling or bifurcation of the distal phalanx of the pollex associated with postaxial polydactyly
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• when each allele is inherited maternally, placenta weight is increased compared to in wild-type mice starting at E14.5
• when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally, placenta weight is 140% of wild-type mice at E15.5
• when each allele is inherited maternally, placenta weight is 230% of wild-type at E16.5
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• when each allele is inherited maternally, 5 of 10 mice exhibit a cleft palate
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• when each allele is inherited maternally, 3 of 4 mice develop adrenal gland cysts and both medullar and cortical cystic abnormalities
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• when each allele is inherited maternally, serum insulin-like growth factor II levels are increase more than 11-fold compared to in wild-type mice
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• when each allele is inherited maternally, mice exhibit an edematous external appearance
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• when each allele is inherited maternally, 2 of 4 mice exhibit accumulation of pericardial fluid unlike in wild-type mice
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• when each allele is inherited maternally
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• when each allele is inherited maternally, 5 of 10 mice exhibit a cleft palate
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• when each allele is inherited maternally, 3 of 4 mice develop adrenal gland cysts and both medullar and cortical cystic abnormalities
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• when each allele is inherited maternally, 20 of 22 mice exhibit large omphalocele consisting of a large portion of the liver present anteriorly and intestinal loops lying posteriorly
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• when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally, mice weight 130% of normal at E18.5
• when each allele is inherited maternally, mice weigh 200% of normal at E16.5 and E17.5
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• when each allele is inherited maternally or when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally
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• when each allele is inherited maternally or when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally, the muscular wall of the heart is hyperplastic and hyperplastic endothelial cells accumulate in the intertrabecular spaces of the ventricles and atria unlike in wild-type mice
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• when each allele is inherited maternally or when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally, heart cell proliferation at E13.5 is increased compared to in wild-type mice
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• when each allele is inherited maternally or when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally, the sternum is split along the entire midline and almost duplicated in total width at E16.5
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• when each allele is inherited maternally, the twin centers in L2 are fused in the midline whereas the L3 and L4 centers remain separate at E16.5
• when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally, the twin ossification centers in L3 are fused at E16.5
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• when each allele is inherited maternally, 5 of 10 mice exhibit a cleft palate
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• when each allele is inherited maternally
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• when each allele is inherited maternally or when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally, heart cell proliferation at E13.5 is increased compared to in wild-type mice
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• when each allele is inherited maternally or when H19tm2Tilg is inherited maternally and Igf2tm1Rob is inherited paternally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• double mutants inheriting the mutant Igf2 allele paternally are larger than mice lacking Igf2
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• defect is seen in double mutants that receive the Igf2 mutant allele from the father
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• double mutants inheriting the mutant allele paternally are larger than mice lacking Igf2
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• defect is seen in double mutants that receive the Igf2 mutant allele from the father
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2rtm1Stw and H19tm2Tilg are inherited maternally and Igf2tm1Rob is inherited paternally, mice die immediately after birth
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• when Igf2rtm1Stw and H19tm2Tilg are inherited maternally and Igf2tm1Rob is inherited paternally, mice exhibit postaxial polydactyly that is confined to a single forelimb
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• when Igf2rtm1Stw and H19tm2Tilg are inherited maternally and Igf2tm1Rob is inherited paternally, mice weigh 135% of wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• placenta size is 67% of normal at E18.5
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• birth weight is 34.4% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, placenta size is 67% of normal at E18.5
• when Igf2tm1Rob and Igf2rtm1Arge are inherited paternally, placenta size is 67% of normal at E18.5
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• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, birth weight is 34.4% of normal
• when Igf2tm1Rob and Igf2rtm1Arge are inherited paternally, birth weight is 33.6% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• placenta size is 67% of normal at E18.5
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• birth weight is 34.4% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• placenta size is 67% of normal at E18.5
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• birth weight is 73.8% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• placenta size is 67% of normal at E18.5
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• birth weight is 73.8% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2rtm2Arge is inherited maternally, placenta size is 67% of normal at E18.5
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• when Igf2rtm2Arge is inherited maternally, birth weight is 73.8% of normal
• when Igf2rtm2Arge is inherited paternally, birth weight is 61.5% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2rtm1Arge is inherited maternally, placenta size is 67% of normal at E18.5
|
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• when Igf2rtm1Arge is inherited maternally, birth weight is 73.8% of normal
• when Igf2rtm1Arge is inherited paternally, birth weight is 61.5% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5
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• when Igf2tm1Rob is inherited paternally, birth weight is 73.8% of normal
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• when Igf2tm1Rob is inherited maternally, birth weight is 140% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5
|
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• when Igf2tm1Rob is inherited paternally, birth weight is 73.8% of normal
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• when Igf2tm1Rob is inherited maternally, birth weight is 140% of normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, placenta size is 67% of normal at E18.5
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• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, birth weight is 73.8% of normal
• when Igf2tm1Rob and Igf2rtm2Arge are inherited paternally, birth weight is 61.5% of normal
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• when Igf2tm1Rob and Igf2rtm2Arge are inherited maternally, birth weight is 140% of normal
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, placenta size is 67% of normal at E18.5
|
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• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, birth weight is 73.8% of normal
• when Igf2tm1Rob and Igf2rtm1Arge are inherited paternally, birth weight is 61.5% of normal
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• when Igf2tm1Rob and Igf2rtm1Arge are inherited maternally, birth weight is 140% of normal
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|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2tm1Rob is inherited paternally, mice are dwarfed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2tm1Rob is inherited paternally, mice are dwarfed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2rtm2Arge is inherited maternally, mice die within 4 weeks of birth
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• when Igf2rtm2Arge is inherited maternally, mice exhibit a waddling gait
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• when Igf2rtm2Arge is inherited maternally, mice are dwarfed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2rtm1Arge is inherited maternally, mice die within 4 weeks of birth
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• when Igf2rtm1Arge is inherited maternally, mice exhibit a waddling gait
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• when Igf2rtm1Arge is inherited maternally, mice are dwarfed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice die within 4 weeks of birth
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• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice are dwarfed
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• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice exhibit a waddling gait
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, mice die within 4 weeks of birth
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• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, mice are dwarfed
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• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, mice exhibit a waddling gait
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• when Igf2rtm2Arge is inherited maternally, mice are viable
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• when Igf2rtm2Arge is inherited maternally, mice are dwarfed
|
| N |
• when Igf2rtm2Arge is inherited maternally, mice are fertile
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• when Igf2rtm1Arge is inherited maternally, mice are viable
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• when Igf2rtm1Arge is inherited maternally, mice are dwarfed
|
| N |
• when Igf2rtm1Arge is inherited maternally, mice are fertile
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice are viable
|
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• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice are dwarfed
|
| N |
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, mice are fertile
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, mice are viable
|
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• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, mice are dwarfed
|
| N |
• when Igf2tm1Rob is inherited paternally and Igf2rtm1Arge is inherited maternally, mice are fertile
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• when Igf2tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5
|
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• when Igf2tm1Rob is inherited paternally, birth weight is 33.6% of normal
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, placenta size is 67% of normal at E18.5
• when Igf2tm1Rob and Igf2rtm2Arge are inherited paternally, placenta size is 67% of normal at E18.5
|
|
• when Igf2tm1Rob is inherited paternally and Igf2rtm2Arge is inherited maternally, birth weight is 34.4% of normal
• when Igf2tm1Rob and Igf2rtm2Arge are inherited paternally, birth weight is 33.6% of normal
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• placenta size is 67% of normal at E18.5
|
|
• birth weight is 34.4% of normal
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• when Igf2rtm1Arge is inherited maternally, placenta size is 67% of normal at E18.5
|
|
• when Igf2rtm1Arge is inherited maternally, birth weight is 34.4% of normal
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• when Igf2tm1Rob is inherited paternally, placenta size is 67% of normal at E18.5
|
|
• when Igf2tm1Rob is inherited paternally, birth weight is 34.4% of normal
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• placenta size is 67% of normal at E18.5
|
|
• birth weight is 33.6% of normal
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• rescue of preweaning lethality observed when Igf2rtm1.1(IGF2R)Arte is inherited maternally
|
| N |
• rescue of postnatal overgrowth observed when Igf2rtm1.1(IGF2R)Arte is inherited maternally
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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