All Phenotypes Pea15a<tm1Chne> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pea15a^tm1Chne
targeted mutation 1, Herve Chneiweiss
MGI:2677021

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pea15a^tm1Chne/Pea15a^tm1Chne	involves: 129S6/SvEvTac * Black Swiss	MGI:2677022
hm2	Pea15a^tm1Chne/Pea15a^tm1Chne	involves: C57BL/6	MGI:4366760

Allelic Composition	Pea15a^tm1Chne/Pea15a^tm1Chne
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pea15a^tm1Chne mutation (1 available); any Pea15a mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:77283 )

• homozygotes display a reduced body weight relative to wild-type littermates

nervous system

nervous system phenotype ( J:77283 )

N	• at 2 months of age, homozygotes display normal brain gross morphology and weight relative to wild-type mice • no obvious differences are observed in the number, morphology, or organization of glial cells, as indicated by GFAP labeling of hippocampal astrocytes

abnormal astrocyte morphology ( J:77283 )

• in culture, primary astrocytes harvested from mutant mice are more sensitive to TNF-induced apoptosis than wild-type astrocytes, as indicated by DAPI, annexin V, and TUNEL staining

cellular

abnormal astrocyte morphology ( J:77283 )

• in culture, primary astrocytes harvested from mutant mice are more sensitive to TNF-induced apoptosis than wild-type astrocytes, as indicated by DAPI, annexin V, and TUNEL staining

Allelic Composition	Pea15a^tm1Chne/Pea15a^tm1Chne
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pea15a^tm1Chne mutation (1 available); any Pea15a mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

increased male germ cell apoptosis ( J:121558 )

• at 8 weeks of age, mutant testes show a significant increase in the number of apoptotic spermatocytes (stages IX and XI) relative to wild-type testes, as revealed by TUNEL analysis

• increased apoptosis of spermatocytes is not restricted to a specific step in spermatocyte development but occurs throughout the epithelial cycle

• in contrast to spermatocytes, spermatogonia remain relatively unaffected

cellular

increased male germ cell apoptosis ( J:121558 )

• at 8 weeks of age, mutant testes show a significant increase in the number of apoptotic spermatocytes (stages IX and XI) relative to wild-type testes, as revealed by TUNEL analysis

• increased apoptosis of spermatocytes is not restricted to a specific step in spermatocyte development but occurs throughout the epithelial cycle

• in contrast to spermatocytes, spermatogonia remain relatively unaffected

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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