Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Pisc mutation
(0 available);
any
Ccne1 mutation
(23 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Pisc mutation
(0 available);
any
Ccne1 mutation
(23 available)
Ccne2tm1Boa mutation
(0 available);
any
Ccne2 mutation
(32 available)
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mortality/aging
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• most are dead at E11.5
• 2 of 10 still had beating hearts at E11.5
• most double homozygotes were still alive at E10.5
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cardiovascular system
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• cranial vascularization at E10.5 like that typical at E9.5
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• 60% showing poorly vascularized yolk sac at E11.5
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embryo
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• 60% showing poorly vascularized yolk sac at E11.5
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• reduced DNA content in trophoblast giant cells
• failure of endoreplication, few cells reach a ploidy of 8N
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growth/size/body
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• no obvious morphological defects at E9.5-11.5
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Pisc mutation
(0 available);
any
Ccne1 mutation
(23 available)
Ccne2tm1Pisc mutation
(0 available);
any
Ccne2 mutation
(32 available)
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Pisc mutation
(0 available);
any
Ccne1 mutation
(23 available)
Ccne2tm1Pisc mutation
(0 available);
any
Ccne2 mutation
(32 available)
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endocrine/exocrine glands
reproductive system
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• phenotype like that of homozygous Ccne2tm1Pisc but more severe
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• phenotype like that of homozygous Ccne2tm1Pisc but more severe
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Pisc mutation
(0 available);
any
Ccne1 mutation
(23 available)
Ccne2tm1Pisc mutation
(0 available);
any
Ccne2 mutation
(32 available)
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mortality/aging
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• expected number of homozygotes through E10.25
• only 50% of expected number of homozygotes found at E10.75
• no live double homozygotes after E11.5
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cardiovascular system
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• observed in embryos rescued by tetraploid complementation
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• abnormal patterning of the aortic arch, possibly resulting from a defect in neural crest migration
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• observed in embryos rescued by tetraploid complementation
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• observed in embryos rescued by tetraploid complementation
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embryo
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• normal morphogenesis and no pathological lesions despite growth retardation at E10.75
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• partial rescue of embryonic lethality by tetraploid complementation proves that a problem exists in the placenta
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• layer of trophoblast giant cells reduced or absent
• greatly reduced DNA content relative to expectation
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growth/size/body
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• normal morphogenesis and no pathological lesions despite growth retardation at E10.75
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hematopoietic system
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• observed in embryos rescued by tetraploid complementation
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• reduced DNA content in megakaryocytes relative to expectation observed in embryos rescued by tetraploid complementation
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immune system
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• reduced DNA content in megakaryocytes relative to expectation observed in embryos rescued by tetraploid complementation
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