Phenotypes associated with this allele

• Allele Symbol: Pgr^tm2Omc
• Allele Name: targeted mutation 2, Orla M Conneely
• Allele ID: MGI:2674932
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pgr^tm2Omc/Pgr^tm2Omc	involves: 129S7/SvEvBrd * C57BL/6	MGI:2674948

Genotype
MGI:2674948

hm1

• Allelic Composition: Pgr^tm2Omc/Pgr^tm2Omc
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:85196 )

♀ • reduction in both ductal sidebranching and development of alveolar lobules during pregnancy, seen as early as 7.5 days of pregnancy

abnormal mammary gland epithelium morphology ( J:85196 )

♀ • mammary glands supplemented for 21 days with pregnancy levels of estrogen and progesterone exhibit a 30% decrease in proliferation of the ductal epithelium

♀ • mammary glands supplemented for 21 days with pregnancy levels of estrogen and progesterone exhibit an increase in apoptosis in the alveolar epithelium

abnormal branching of the mammary ductal tree ( J:85196 )

♀ • reduction in the ductal sidebranching during pregnancy

♀ • mammary glands from ovariectomized mutants supplemented for 21 days with pregnancy levels of estrogen and progesterone display a decrease in ductal sidebranching

abnormal mammary gland alveolus morphology ( J:85196 )

♀ • reduction in the development of alveolar lobules during pregnancy

♀ • at day 1 of lactation, glands show lower density of alveolar lobules than wild-type glands, however they do not appear underdeveloped

♀ • mammary glands from ovariectomized mutants supplemented for 21 days with pregnancy levels of estrogen and progesterone display a decrease in lobuloalveolar development

abnormal lactation ( J:85196 )

♀ • even though females are able to lactate, offspring of homozygous mothers are growth retarded independent of their genotype, indicating lactational defects

reproductive system

reproductive system phenotype ( J:85196 )

N • in contrast to female mice lacking isoform A, female mice ovulate normally and are fertile

abnormal mammary gland growth during pregnancy ( J:85196 )

♀ • reduction in both ductal sidebranching and development of alveolar lobules during pregnancy, seen as early as 7.5 days of pregnancy

integument

abnormal mammary gland growth during pregnancy ( J:85196 )

♀ • reduction in both ductal sidebranching and development of alveolar lobules during pregnancy, seen as early as 7.5 days of pregnancy

abnormal mammary gland epithelium morphology ( J:85196 )

♀ • mammary glands supplemented for 21 days with pregnancy levels of estrogen and progesterone exhibit a 30% decrease in proliferation of the ductal epithelium

♀ • mammary glands supplemented for 21 days with pregnancy levels of estrogen and progesterone exhibit an increase in apoptosis in the alveolar epithelium

abnormal branching of the mammary ductal tree ( J:85196 )

♀ • reduction in the ductal sidebranching during pregnancy

♀ • mammary glands from ovariectomized mutants supplemented for 21 days with pregnancy levels of estrogen and progesterone display a decrease in ductal sidebranching

abnormal mammary gland alveolus morphology ( J:85196 )

♀ • reduction in the development of alveolar lobules during pregnancy

♀ • at day 1 of lactation, glands show lower density of alveolar lobules than wild-type glands, however they do not appear underdeveloped

♀ • mammary glands from ovariectomized mutants supplemented for 21 days with pregnancy levels of estrogen and progesterone display a decrease in lobuloalveolar development

abnormal lactation ( J:85196 )

♀ • even though females are able to lactate, offspring of homozygous mothers are growth retarded independent of their genotype, indicating lactational defects