Phenotypes associated with this allele

• Allele Symbol: Brd4^{Gt(pGT1.8TM)ST132Nimr}
• Allele Name: gene trap ST132, National Institute for Medical Research
• Allele ID: MGI:2674141
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brd4^Gt(pGT1.8TM)ST132Nimr/Brd4^Gt(pGT1.8TM)ST132Nimr	involves: 129P2/Ola * C57BL/6J	MGI:2674194
ht2	Brd4^Gt(pGT1.8TM)ST132Nimr/Brd4^+	involves: 129P2/Ola * C57BL/6J	MGI:2674195

Genotype
MGI:2674194

hm1

• Allelic Composition: Brd4^{Gt(pGT1.8TM)ST132Nimr}/Brd4^{Gt(pGT1.8TM)ST132Nimr}
• Genetic Background: involves: 129P2/Ola * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:76662 )

• homozygous embryos die between E3.0 and E8.0

embryo

inner cell mass degeneration ( J:76662 )

• by E8.0, the inner cell mass had degenerated completely

Genotype
MGI:2674195

ht2

• Allelic Composition: Brd4^{Gt(pGT1.8TM)ST132Nimr}/Brd4⁺
• Genetic Background: involves: 129P2/Ola * C57BL/6J

mortality/aging

postnatal lethality, incomplete penetrance ( J:76662 )

• 50% of heterozygous animals die within the first two weeks of birth

craniofacial

abnormal craniofacial bone morphology ( J:76662 )

short mandible ( J:76662 )

short premaxilla ( J:76662 )

• short incisive bone

short nasal bone ( J:76662 )

• short and bent nasal bone

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:76662 )

♂ • lacking spermatogenic cells

growth/size/body

short nasal bone ( J:76662 )

• short and bent nasal bone

embryonic growth retardation ( J:76662 )

• at E10 through birth, heterozygous embryos weighed 25% less than littermates;

postnatal growth retardation ( J:76662 )

• after birth, heterozygous embryos weighed 10% less than littermates

liver/biliary system

abnormal hepatocyte morphology ( J:76662 )

• abnormal nuclear morphology; enlarged, or cells contained two nuclei; degenerated and/or necrotic hepatocytes detected

reproductive system

abnormal seminiferous tubule morphology ( J:76662 )

♂ • lacking spermatogenic cells

abnormal spermatogenesis ( J:76662 )

♂ • impaired spermatogenesis

abnormal epididymis epithelium morphology ( J:76662 )

♂ • cells lining ducts of abnormal size/shape and abnormal nuclear morphology

abnormal vas deferens morphology ( J:76662 )

♂ • cells lining ducts of abnormal size/shape and abnormal nuclear morphology

skeleton

abnormal craniofacial bone morphology ( J:76662 )

short mandible ( J:76662 )

short premaxilla ( J:76662 )

• short incisive bone

short nasal bone ( J:76662 )

• short and bent nasal bone

vision/eye

cataract ( J:76662 )

• seen in 7 of 34 animals

microphthalmia ( J:76662 )

• seen in 4 of 34 animals

embryo

embryonic growth retardation ( J:76662 )

• at E10 through birth, heterozygous embryos weighed 25% less than littermates;

integument

mixed cellular infiltration to dermis ( J:76662 )

• increased number of neutrophils and mature fibrocytes in dermis

thick epidermis ( J:76662 )

respiratory system

short nasal bone ( J:76662 )

• short and bent nasal bone