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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fancatm1Wong
targeted mutation 1, Jasmine C Y Wong
MGI:2674094
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fancatm1Wong/Fancatm1Wong either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1) MGI:3047101
hm2
 		Fancatm1Wong/Fancatm1Wong either: 129S6/SvEvTac or C57BL/6 MGI:3047139
hm3
 		Fancatm1Wong/Fancatm1Wong involves: 129S6/SvEvTac MGI:3047126
hm4
 		Fancatm1Wong/Fancatm1Wong involves: C57BL/6 MGI:3047131


Genotype
MGI:3047101
hm1
Allelic
Composition		 Fancatm1Wong/Fancatm1Wong
Genetic
Background		 either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancatm1Wong mutation (0 available); any Fanca mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:85108 )
N
• while not statistically significant due to small sample size, tumors were observed in 33% of mice on a mixed genetic background involving 129S6/SvEvTac and CD1 and in 11.7% of mice on a 129S6/SvEvTac coisogenic background; whereas no tumors were observed in wild-type mice

endocrine/exocrine glands
seminiferous tubule degeneration ( J:85108 )
• about 3% were severely degenerated, on a 129S6/SvEvTac genetic background

reproductive system
seminiferous tubule degeneration ( J:85108 )
• about 3% were severely degenerated, on a 129S6/SvEvTac genetic background




Genotype
MGI:3047139
hm2
Allelic
Composition		 Fancatm1Wong/Fancatm1Wong
Genetic
Background		 either: 129S6/SvEvTac or C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancatm1Wong mutation (0 available); any Fanca mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
ovary hemorrhage ( J:85108 )
• ovaries appeared hemorrhagic
ovary cyst ( J:85108 )
• ovaries contained many cysts

reproductive system
ovary hemorrhage ( J:85108 )
• ovaries appeared hemorrhagic
ovary cyst ( J:85108 )
• ovaries contained many cysts

cardiovascular system
ovary hemorrhage ( J:85108 )
• ovaries appeared hemorrhagic

growth/size/body
ovary cyst ( J:85108 )
• ovaries contained many cysts




Genotype
MGI:3047126
hm3
Allelic
Composition		 Fancatm1Wong/Fancatm1Wong
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancatm1Wong mutation (0 available); any Fanca mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
early reproductive senescence ( J:85108 )
• females exhibited premature reproductive senescence

reproductive system
decreased germ cell number ( J:85108 )
• observed in both 129S6/SvEvTac and C57BL/6 genetic backgrounds, however a more severe depletion was observed in the C57BL/6 background
seminiferous tubule degeneration ( J:85108 )
• ~3% were severely degenerated, on a 129S6/SvEvTac genetic background
small testis ( J:85108 )
• ~2-fold smaller than those of heterozygotes on a 129S6/SvEvTac coisogenic background
early reproductive senescence ( J:85108 )
• females exhibited premature reproductive senescence
abnormal spermatogenesis ( J:85108 )
• a proportion of spermatocytes progressed through spermatogenesis to produce functional spermatozoa
abnormal male meiosis ( J:85108 )
• elevated frequency of mispaired meiotic chromosomes
reduced female fertility ( J:85108 )
• putatively due to a diminished population of primordial germ cells during migration into the genital ridge
• male fertility was not impaired

endocrine/exocrine glands
seminiferous tubule degeneration ( J:85108 )
• ~3% were severely degenerated, on a 129S6/SvEvTac genetic background
small testis ( J:85108 )
• ~2-fold smaller than those of heterozygotes on a 129S6/SvEvTac coisogenic background

cellular
decreased germ cell number ( J:85108 )
• observed in both 129S6/SvEvTac and C57BL/6 genetic backgrounds, however a more severe depletion was observed in the C57BL/6 background




Genotype
MGI:3047131
hm4
Allelic
Composition		 Fancatm1Wong/Fancatm1Wong
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancatm1Wong mutation (0 available); any Fanca mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial

endocrine/exocrine glands

growth/size/body
decreased body weight ( J:85108 )
• Background Sensitivity: observed on a C57BL/6 genetic background
postnatal growth retardation ( J:85108 )
• observed on a C57BL/6 genetic background

reproductive system
decreased germ cell number ( J:85108 )
• Background Sensitivity: observed in both 129S6/SvEvTac and C57BL/6 genetic backgrounds, however a more severe depletion was observed in the C57BL/6 background

skeleton

vision/eye
microphthalmia ( J:85108 )
• often observed in conjunction with craniofacial abnormalities
• Background Sensitivity: exhibited on a C57BL/6 genetic background

cellular
decreased germ cell number ( J:85108 )
• Background Sensitivity: observed in both 129S6/SvEvTac and C57BL/6 genetic backgrounds, however a more severe depletion was observed in the C57BL/6 background

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Fanconi anemia complementation group A DOID:0111095 OMIM:227650
 J:85108




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory