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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Shank2+
wild type
MGI:2671989
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Shank2tm1.1Tmb/Shank2+ B6.129-Shank2tm1.1Tmb MGI:5435703
ht2
 		Shank2tm1Mgle/Shank2+ B6.129S4-Shank2tm1Mgle MGI:5437481


Genotype
MGI:5435703
ht1
Allelic
Composition		 Shank2tm1.1Tmb/Shank2+
Genetic
Background		 B6.129-Shank2tm1.1Tmb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank2tm1.1Tmb mutation (0 available); any Shank2 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

behavior/neurological
increased locomotor activity ( J:186719 )
• in an open field assay

nervous system
abnormal excitatory postsynaptic potential ( J:186719 )
• field excitatory postsynaptic potentials are decreased by about 40% in CA1 pyramidal cells in acute hippocampal slices from mice at age P21-P28




Genotype
MGI:5437481
ht2
Allelic
Composition		 Shank2tm1Mgle/Shank2+
Genetic
Background		 B6.129S4-Shank2tm1Mgle
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank2tm1Mgle mutation (1 available); any Shank2 mutation (94 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:186718 )
N
• no defects in social interaction, repetitive behaviors or anxiety-like behaviors unlike in homozygous mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory