Analysis Tools
growth/size/body
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• at 2 months of age
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pigmentation
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• increase in the spacing between pigment bands and occassional absence of pigment in the midshaft
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• becomes more notable with age
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behavior/neurological
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• significantly decreased latency in rotarod test
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nervous system
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• abnormal accumulation of proteins in perinuclear areas
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• abnormal accumulation of proteins in the dendrites
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• at 2 months of age but not at 1 month of age
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• loss of Purkinje cells in lobule IX at 2 months of age
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• loss of Purkinje cells in lobule VI at 2 months of age
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• loss of Purkinje cells in lobule VII at 2 months of age
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• loss of Purkinje cells in lobule X at 2 months of age
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• abnormal filamentous lesions in the cerebellum of all 30-day-old mice
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cellular
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• impaired ER/Golgi and/or intra-Golgi trafficking in melanocytes
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integument
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• increase in the spacing between pigment bands and occassional absence of pigment in the midshaft
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• becomes more notable with age
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