All Phenotypes Lmo2<tm2(cre)Thr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lmo2^tm2(cre)Thr
targeted mutation 2, Terence H Rabbitts
MGI:2671438

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lmo2^tm2(cre)Thr/Lmo2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4421774
cn2	Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺ Smim3^tm1Anjm/Smim3⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:4421776
cn3	Smim3^tm1Anjm/Smim3⁺ Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺ Trp53^tm1Brd/Trp53⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:4421779
cn4	Smim3^tm1Anjm/Smim3⁺ Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺ Trp53^tm1Brd/Trp53^tm1Brd	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:4421780
cn5	Arsi^tm1Anjm/Arsi⁺ Csf1r^tm1Anjm/Csf1r⁺ Lmo2^tm2(cre)Thr/Lmo2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4421695
cn6	Smim3^tm1Anjm/Smim3⁺ Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:4421775
cn7	Lmo2^tm2(cre)Thr/Lmo2⁺ Kmt2a^tm1Thr/Kmt2a⁺ Mllt1^tm1Thr/Mllt1⁺	involves: 129S/SvEv	MGI:2671953

Allelic Composition	Lmo2^tm2(cre)Thr/Lmo2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmo2^tm2(cre)Thr mutation (0 available); any Lmo2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:155870 )

• decreased granulocyte/macrophage colony-forming units

abnormal megakaryocyte progenitor cell morphology ( J:155870 )

• megakaryocyte colony-forming units numbers of are depressed in the bone marrow

decreased erythrocyte cell number ( J:155870 )

• a reduction in the number of circulating RBCs

decreased hemoglobin content ( J:155870 )

increased mean corpuscular volume ( J:155870 )

decreased granulocyte number ( J:155870 )

• total granulocyte numbers are lower in the blood

thrombocytopenia ( J:155870 )

decreased monocyte cell number ( J:155870 )

• total monocyte numbers are lower in the blood

immune system

decreased granulocyte number ( J:155870 )

• total granulocyte numbers are lower in the blood

decreased monocyte cell number ( J:155870 )

• total monocyte numbers are lower in the blood

Allelic Composition	Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺ Smim3^tm1Anjm/Smim3⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Anjm mutation (0 available); any Cd74 mutation (37 available)
Lmo2^tm2(cre)Thr mutation (0 available); any Lmo2 mutation (30 available)
Smim3^tm1Anjm mutation (0 available); any Smim3 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased granulocyte monocyte progenitor cell number ( J:155870 )

• a decrease in granulocyte/macrophage colony-forming units in spleen and bone marrow

• by flow cytometry, there is a reduced number of granulocyte-monocyte progenitors in the bone marrow

decreased erythroid progenitor cell number ( J:155870 )

• a decrease in erythroid colony-forming units in the bone marrow

decreased erythrocyte cell number ( J:155870 )

• there are a reduced numbers of circulating red blood cells

increased mean corpuscular volume ( J:155870 )

thrombocytopenia ( J:155870 )

decreased hematopoietic stem cell number ( J:155870 )

• in bone marrow and spleen

decreased megakaryocyte-erythroid progenitor cell number ( J:155870 )

• by flow cytometry, there is a reduced number of megakaryocytic-erythroid progenitors in the bone marrow

skeleton

abnormal bone marrow morphology ( J:155870 )

• bone marrow dysplasia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chromosome 5q deletion syndrome		DOID:0090016	OMIM:153550	J:155870

Allelic Composition	Smim3^tm1Anjm/Smim3⁺ Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺ Trp53^tm1Brd/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased granulocyte monocyte progenitor cell number ( J:155870 )

• a decrease in granulocyte/macrophage colony-forming units in bone marrow

• by flow cytometry, there is a reduction in granulocyte-monocyte progenitors in the bone marrow

decreased erythroid progenitor cell number ( J:155870 )

• as measured by erythroid colony-forming units in bone marrow

decreased erythrocyte cell number ( J:155870 )

• a reduced number of circulating red blood cells

increased mean corpuscular volume ( J:155870 )

thrombocytopenia ( J:155870 )

decreased hematopoietic stem cell number ( J:155870 )

• in bone marrow and spleen

decreased megakaryocyte-erythroid progenitor cell number ( J:155870 )

• by flow cytometry, there is a reduction in megakaryocytic-erythroid progenitors in the bone marrow

Allelic Composition	Smim3^tm1Anjm/Smim3⁺ Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺ Trp53^tm1Brd/Trp53^tm1Brd
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:155870 )

N	• absence of Trp53 expression completely rescues hematopoetic defects seen in mutant mice wild-type for Trp53

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chromosome 5q deletion syndrome		DOID:0090016	OMIM:153550	J:155870

Allelic Composition	Arsi^tm1Anjm/Arsi⁺ Csf1r^tm1Anjm/Csf1r⁺ Lmo2^tm2(cre)Thr/Lmo2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arsi^tm1Anjm mutation (0 available); any Arsi mutation (72 available)
Csf1r^tm1Anjm mutation (0 available); any Csf1r mutation (70 available)
Lmo2^tm2(cre)Thr mutation (0 available); any Lmo2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:155870 )

N	• no substantial changes in RBC numbers or hemoglobin concentrations

Allelic Composition	Smim3^tm1Anjm/Smim3⁺ Cd74^tm1Anjm/Cd74⁺ Lmo2^tm2(cre)Thr/Lmo2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

macrocytic anemia ( J:155870 )

abnormal bone marrow cell number ( J:155870 )

• an elevated proportion of mast cells in the bone marrow

decreased bone marrow cell number ( J:155870 )

• a reduced number of cells are flushed from the femurs

• histological bone marrow sections have mild to high hypocellularity

decreased granulocyte monocyte progenitor cell number ( J:155870 )

• decreased granulocyte/macrophage colony-forming units

• by flow cytometry, a reduction in granulocyte-monocyte progenitors in the bone marrow

abnormal megakaryocyte morphology ( J:155870 )

• monolobulated megakaryocytes in the bone marrow

decreased erythroid progenitor cell number ( J:155870 )

• a decreased number of erythroid colony-forming units

abnormal megakaryocyte progenitor cell morphology ( J:155870 )

• a decreased number of megakaryocyte colony-forming units

• considerably fewer in the bone marrow by flow cytometry

abnormal blood cell morphology ( J:155870 )

• pencil shaped cells are present in blood smears

abnormal common myeloid progenitor cell morphology ( J:155870 )

• striking decrease in the common myeloid progenitor - megakaryocytic-erythroid progenitor lineage

abnormal erythropoiesis ( J:155870 )

• prominent erythroid dysplasia, dyserythropoiesis

decreased erythrocyte cell number ( J:155870 )

decreased hemoglobin content ( J:155870 )

increased mean corpuscular volume ( J:155870 )

increased red blood cell distribution width ( J:155870 )

• increase in the mean red blood cell distribution width

macrocytosis ( J:155870 )

• in bone marrow and peripheral blood

decreased granulocyte number ( J:155870 )

• total granulocyte numbers are lower in the blood

abnormal mast cell morphology ( J:155870 )

• an elevated proportion of mast cells in the bone marrow

thrombocytopenia ( J:155870 )

• modest

decreased monocyte cell number ( J:155870 )

• in the blood

decreased hematopoietic stem cell number ( J:155870 )

• in bone marrow and spleen

decreased megakaryocyte-erythroid progenitor cell number ( J:155870 )

• by flow cytometry, a reduction in megakaryocytic-erythroid progenitors in the bone marrow

immune system

decreased granulocyte number ( J:155870 )

• total granulocyte numbers are lower in the blood

abnormal mast cell morphology ( J:155870 )

• an elevated proportion of mast cells in the bone marrow

decreased monocyte cell number ( J:155870 )

• in the blood

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chromosome 5q deletion syndrome		DOID:0090016	OMIM:153550	J:155870

Allelic Composition	Lmo2^tm2(cre)Thr/Lmo2⁺ Kmt2a^tm1Thr/Kmt2a⁺ Mllt1^tm1Thr/Mllt1⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2a^tm1Thr mutation (0 available); any Kmt2a mutation (137 available)
Lmo2^tm2(cre)Thr mutation (0 available); any Lmo2 mutation (30 available)
Mllt1^tm1Thr mutation (0 available); any Mllt1 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:84518 )

• 100% of mutants either die or are sacrified due to ill health by 120 days of age

neoplasm

increased hemolymphoid system tumor incidence ( J:100794 )

• all mice develop hematological malignancies

• infiltration of malignant cells occurs in the liver, kidney, lungs and lymph nodes

increased leukemia incidence ( J:84518 , J:100794 )

• develop myeloid leukemias as early as 1.5 months of age (J:84518)

• leukemic cells invade the spleen and into peripheral organs such as liver and kidneys with perivascular deposits of tumor cells in liver and in between glomerili of kidney (J:84518)

• mice have myelo-proliferative-like myeloid leukemia (J:100794)

hematopoietic system

enlarged spleen ( J:84518 , J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)

abnormal spleen red pulp morphology ( J:100794 )

• red and white pulp architecture is lost

abnormal spleen white pulp morphology ( J:100794 )

• red and white pulp architecture is lost

immune system

enlarged spleen ( J:84518 , J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)

abnormal spleen red pulp morphology ( J:100794 )

• red and white pulp architecture is lost

abnormal spleen white pulp morphology ( J:100794 )

• red and white pulp architecture is lost

liver/biliary system

pale liver ( J:84518 )

renal/urinary system

pale kidney ( J:84518 )

growth/size/body

enlarged spleen ( J:84518 , J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)

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