All Phenotypes Itga2b<tm1(GFP/cre)Emam> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Itga2b^{tm1(GFP/cre)Emam}
targeted mutation 1, Nikla R Emambokus
MGI:2670210

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itga2b^{tm1(GFP/cre)Emam}/Itga2b^{tm1(GFP/cre)Emam}	involves: 129S6/SvEvTac * C57BL/6	MGI:2670217
cn2	Itga2b^{tm1(GFP/cre)Emam}/Itga2b^{tm1(GFP/cre)Emam} Rhoa^tm1Csab/Rhoa^tm1Csab Tg(ITGA2B)3Mako/0 Tg(Pf4-icre)Q3Rsko/0	involves: 129S6/SvEvTac * C57BL/6	MGI:5548168

Allelic Composition	Itga2b^{tm1(GFP/cre)Emam}/Itga2b^{tm1(GFP/cre)Emam}
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2b^{tm1(GFP/cre)Emam} mutation (0 available); any Itga2b mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal embryonic hematopoiesis ( J:84564 )

• 1.5- to 2-fold increase in myeloid colonies from E9.5 yolk sac

abnormal definitive hematopoiesis ( J:84564 )

• increase in the number of hematopoietic progenitor cells in the yolk sac, fetal liver, and bone marrow

• 1.5-fold increase in colony forming unit numbers and colony size from adult spleen cells

anemia ( J:84564 )

• observed in some mice due to a bleeding tendancy

thrombocytopenia ( J:84564 )

• thrombocytopenia is some mice

increased hematopoietic stem cell number ( J:84564 )

• 1.5- to 2-fold increase in hematopoietic progenitors in the adult bone marrow

abnormal platelet physiology ( J:84564 )

• dysfunctional platelets

homeostasis/metabolism

abnormal platelet physiology ( J:84564 )

• dysfunctional platelets

cellular

abnormal cell adhesion ( J:84564 )

• adhesion of bone marrow cells to fibronectin is impaired

embryo

abnormal embryonic hematopoiesis ( J:84564 )

• 1.5- to 2-fold increase in myeloid colonies from E9.5 yolk sac

Allelic Composition	Itga2b^{tm1(GFP/cre)Emam}/Itga2b^{tm1(GFP/cre)Emam} Rhoa^tm1Csab/Rhoa^tm1Csab Tg(ITGA2B)3Mako/0 Tg(Pf4-icre)Q3Rsko/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2b^{tm1(GFP/cre)Emam} mutation (0 available); any Itga2b mutation (45 available)
Rhoa^tm1Csab mutation (0 available); any Rhoa mutation (70 available)
Tg(ITGA2B)3Mako mutation (0 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal megakaryocyte morphology ( J:204459 )

• cultured megakaryocytes derived from fetal liver E13.5 exhibit altered ploidy distribution (modal ploidy 16N compared with normal 2N) and larger size compared with control cells

• megakaryocytes are stiffer than in control cells

abnormal megakaryocyte differentiation ( J:204459 )

• in vivo platelet production is impaired

decreased megakaryocyte cell number ( J:204459 )

cellular

abnormal megakaryocyte differentiation ( J:204459 )

• in vivo platelet production is impaired

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23