Analysis Tools
liver/biliary system
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• hepatocellular swelling without lipidosis, characterized by abundant, lightly granular, pale, eosinophilic cytoplasm, is observed in some animals
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• individual hepatocyte necrosis or apoptosis, and a few scattered foci of necrosis are seen, sometimes with secondary neutrophilic infiltrates, in some livers
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• liver weight/body weight ratio is significantly increased in males and females, with no significant change in body weight observed
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pale liver
(
J:84422
)
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• liver is lighter red in color compared to normal liver
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homeostasis/metabolism
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• at 3 weeks of age, plasma total cholesterol is decreased 30% compared to controls and is decreased 80% at 2 months of age
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• liver microsomal NADPH-cytochrome P450 activity toward cytochrome c, NKK, and acetominophen (AP), as well heme oxygenase (HO) activity are decreased in mice at 3 weeks
• at 2 months of age, mice have 5-8% of normal activity levels toward NKK and AP, and barely detectable HO activity
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behavior/neurological
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• mice are still unconscious 10 h after a single 60 mg/kg dose of pentobarbital, unlike controls which regained righting reflex after about 30 min
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growth/size/body
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• liver weight/body weight ratio is significantly increased in males and females, with no significant change in body weight observed
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cellular
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• individual hepatocyte necrosis or apoptosis, and a few scattered foci of necrosis are seen, sometimes with secondary neutrophilic infiltrates, in some livers
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