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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbxa2rtm1Sna
targeted mutation 1, Shuh Narumiya
MGI:2667333
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbxa2rtm1Sna/Tbxa2rtm1Sna B6.Cg-Tbxa2rtm1Sna MGI:5517587
hm2
 		Tbxa2rtm1Sna/Tbxa2rtm1Sna either: (involves: 129/Ola * BALB/c) or (involves: 129/Ola * C57BL/6) MGI:2670653


Genotype
MGI:5517587
hm1
Allelic
Composition		 Tbxa2rtm1Sna/Tbxa2rtm1Sna
Genetic
Background		 B6.Cg-Tbxa2rtm1Sna
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbxa2rtm1Sna mutation (1 available); any Tbxa2r mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to type I hypersensitivity reaction ( J:197334 )
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit slightly increased dye extravasation (a measure of edema) compared with wild-type mice

homeostasis/metabolism
edema ( J:197334 )
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit slightly increased dye extravasation (a measure of edema) compared with wild-type mice




Genotype
MGI:2670653
hm2
Allelic
Composition		 Tbxa2rtm1Sna/Tbxa2rtm1Sna
Genetic
Background		 either: (involves: 129/Ola * BALB/c) or (involves: 129/Ola * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbxa2rtm1Sna mutation (1 available); any Tbxa2r mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged spleen ( J:84085 )
• splenomegaly seen in F2 mice on a C57BL/6 background

immune system
enlarged spleen ( J:84085 )
• splenomegaly seen in F2 mice on a C57BL/6 background
abnormal lymph node morphology ( J:84085 )
• zonal structure of lymph nodes disrupted
• follicles with T and B cells found throughout the nodes
enlarged lymph nodes ( J:84085 )
• develops with age (at 30 weeks) in cervical lymph nodes
abnormal cervical lymph node morphology ( J:84085 )
• lymphadenopathy develops with age (seen at 30 weeks)
abnormal immune system physiology ( J:84085 )
• decreased adhesion of dendritic cells and T cells
abnormal type I hypersensitivity reaction ( J:84085 )
• enhanced contact hypersensitivity
abnormal immune serum protein physiology ( J:84085 )
• immunoglobulin production is enhanced in F2 mice on a C57BL/6 background but not after further backcrosses or on the BALB/c background

growth/size/body
enlarged spleen ( J:84085 )
• splenomegaly seen in F2 mice on a C57BL/6 background




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory