Phenotypes associated with this allele

• Allele Symbol: Cd81^tm1Tmiy
• Allele Name: targeted mutation 1, Toru Miyazaki
• Allele ID: MGI:2665072
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd81^tm1Tmiy/Cd81^tm1Tmiy	involves: 129/Sv * C57BL/6	MGI:2672797
cx2	Cd81^tm1Tmiy/Cd81^tm1Tmiy Cd9^tm1Mek/Cd9^tm1Mek	involves: 129/Sv * C57BL/6	MGI:2672816

Genotype
MGI:2672797

hm1

• Allelic Composition: Cd81^tm1Tmiy/Cd81^tm1Tmiy
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell proliferation ( J:41830 )

• reduced B cell proliferation after surface IgM crosslinking

• T-cell dependent B-cell activation partially reduced

increased B cell proliferation ( J:41830 )

• enhanced proliferation after stimulation with anti-CD4 Ab or LPS

abnormal T cell proliferation ( J:41830 )

• enhanced proliferation after stimulaiton with anti-CD3 Ab, concanavalin A (ConA), or in mixed lymphocyte reaction (MLR)

abnormal B cell differentiation ( J:41830 )

• reduced cell surface expression of CD19

• CD19 not down regulated

decreased B-1 B cell number ( J:41830 )

• reduction in peritoneal B1 cells

abnormal macrophage physiology ( J:83795 )

• homozygotes display enhanced formation of multinucleated giant cells after stimulation

immune system

decreased B cell proliferation ( J:41830 )

• reduced B cell proliferation after surface IgM crosslinking

• T-cell dependent B-cell activation partially reduced

increased B cell proliferation ( J:41830 )

• enhanced proliferation after stimulation with anti-CD4 Ab or LPS

abnormal T cell proliferation ( J:41830 )

• enhanced proliferation after stimulaiton with anti-CD3 Ab, concanavalin A (ConA), or in mixed lymphocyte reaction (MLR)

abnormal macrophage physiology ( J:83795 )

• homozygotes display enhanced formation of multinucleated giant cells after stimulation

abnormal immune system cell morphology ( J:41830 )

abnormal B cell differentiation ( J:41830 )

• reduced cell surface expression of CD19

• CD19 not down regulated

decreased B-1 B cell number ( J:41830 )

• reduction in peritoneal B1 cells

cellular

decreased B cell proliferation ( J:41830 )

• reduced B cell proliferation after surface IgM crosslinking

• T-cell dependent B-cell activation partially reduced

increased B cell proliferation ( J:41830 )

• enhanced proliferation after stimulation with anti-CD4 Ab or LPS

abnormal T cell proliferation ( J:41830 )

• enhanced proliferation after stimulaiton with anti-CD3 Ab, concanavalin A (ConA), or in mixed lymphocyte reaction (MLR)

Genotype
MGI:2672816

cx2

• Allelic Composition: Cd81^tm1Tmiy/Cd81^tm1Tmiy; Cd9^tm1Mek/Cd9^tm1Mek
• Genetic Background: involves: 129/Sv * C57BL/6

growth/size/body

decreased body size ( J:83795 )

• mice are viable in spite of smaller body size

hematopoietic system

abnormal definitive hematopoiesis ( J:83795 )

increased osteoclast cell number ( J:83795 )

• 1.5X increase in osteoclast numbers

abnormal macrophage physiology ( J:83795 )

• spontaneous formation of multinucleated giant cells

immune system

increased osteoclast cell number ( J:83795 )

• 1.5X increase in osteoclast numbers

abnormal macrophage physiology ( J:83795 )

• spontaneous formation of multinucleated giant cells

respiratory system

abnormal pulmonary alveolus morphology ( J:83795 )

• alveolar airspace enlargement

skeleton

increased osteoclast cell number ( J:83795 )

• 1.5X increase in osteoclast numbers

decreased bone mineral density ( J:83795 )

abnormal skeleton development ( J:83795 )