All Phenotypes Pafah1b3<tm1Cla> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pafah1b3^tm1Cla
targeted mutation 1, Gary D Clark
MGI:2665018

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pafah1b3^tm1Cla/Pafah1b3^tm1Cla	involves: 129S6/SvEvTac	MGI:2670334
cx2	Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} Pafah1b3^tm1Cla/Pafah1b3^tm1Cla	involves: 129S6/SvEvTac	MGI:2669854
cx3	Pafah1b1^tm1Awb/Pafah1b1⁺ Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} Pafah1b3^tm1Cla/Pafah1b3^tm1Cla	involves: 129S6/SvEvTac	MGI:2669856

Allelic Composition	Pafah1b3^tm1Cla/Pafah1b3^tm1Cla
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b3^tm1Cla mutation (0 available); any Pafah1b3 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:83818 )

N	• gene product is not required for embryonic and early postnatal development

reproductive system

reproductive system phenotype ( J:83818 )

N	• both males and females fertile • testis weight essentially equal to that of wild-type mice

Allelic Composition	Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} Pafah1b3^tm1Cla/Pafah1b3^tm1Cla
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b2^{Gt(Betageo)1Cla} mutation (0 available); any Pafah1b2 mutation (20 available)
Pafah1b3^tm1Cla mutation (0 available); any Pafah1b3 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Testicular phenotypes of mice having various combinations of Pafah1b1^tm1Awb, Pafah1b2^{Gt(Betageo)1Cla} and Pafah1b3^tm1Cla alleles

reproductive system

decreased male germ cell number ( J:83818 )

• germ cell depletion is more severe than in the single Pafah1b2 homozygote

multinucleated giant male germ cells ( J:83818 )

• multinucleated giant cells are seen in the seminiferous epithelium

abnormal testis morphology ( J:83818 )

• testis tubular structures are less obvious and the lumen is small

decreased testis weight ( J:83818 )

• testis weigh about 30% of that of control mice

abnormal sperm number ( J:83818 )

arrest of spermatogenesis ( J:83818 )

• disruption occurs at the initiation phase of spermatogenesis

male infertility ( J:83818 )

• males are infertile, however female fertility is unaffected

endocrine/exocrine glands

abnormal testis morphology ( J:83818 )

• testis tubular structures are less obvious and the lumen is small

decreased testis weight ( J:83818 )

• testis weigh about 30% of that of control mice

cellular

decreased male germ cell number ( J:83818 )

• germ cell depletion is more severe than in the single Pafah1b2 homozygote

multinucleated giant male germ cells ( J:83818 )

• multinucleated giant cells are seen in the seminiferous epithelium

Allelic Composition	Pafah1b1^tm1Awb/Pafah1b1⁺ Pafah1b2^{Gt(Betageo)1Cla}/Pafah1b2^{Gt(Betageo)1Cla} Pafah1b3^tm1Cla/Pafah1b3^tm1Cla
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b1^tm1Awb mutation (0 available); any Pafah1b1 mutation (159 available)
Pafah1b2^{Gt(Betageo)1Cla} mutation (0 available); any Pafah1b2 mutation (20 available)
Pafah1b3^tm1Cla mutation (0 available); any Pafah1b3 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Testicular phenotypes of mice having various combinations of Pafah1b1^tm1Awb, Pafah1b2^{Gt(Betageo)1Cla} and Pafah1b3^tm1Cla alleles

reproductive system

reproductive system phenotype ( J:83818 )

N	• males are fertile

decreased male germ cell number ( J:83818 )

• some degenerating germ cells are seen

multinucleated giant male germ cells ( J:83818 )

abnormal seminiferous tubule epithelium morphology ( J:83818 )

• occasional multinucleated giant cells are seen in the seminiferous epithelium

decreased testis weight ( J:83818 )

• testis weigh about 20% less than that of control mice

cellular

decreased male germ cell number ( J:83818 )

• some degenerating germ cells are seen

multinucleated giant male germ cells ( J:83818 )

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:83818 )

• occasional multinucleated giant cells are seen in the seminiferous epithelium

decreased testis weight ( J:83818 )

• testis weigh about 20% less than that of control mice

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