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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Acetm4Keb
targeted mutation 4, Kenneth E Bernstein
MGI:2665017
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Acetm4Keb/Acetm4Keb involves: 129S1/Sv * 129X1/SvJ MGI:3720679
cx2
 		Acetm4Keb/Acetm4Keb
Bdkrb2tm1Jfh/Bdkrb2tm1Jfh 		involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:3720680


Genotype
MGI:3720679
hm1
Allelic
Composition		 Acetm4Keb/Acetm4Keb
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm4Keb mutation (0 available); any Ace mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney morphology ( J:83894 )
• renal histology is abnormal
abnormal kidney vasculature morphology ( J:83894 )
• intrarenal arterioles are thickened
abnormal kidney pelvis morphology ( J:83894 )
• the kidney pelvis is widened

homeostasis/metabolism

cardiovascular system
abnormal kidney vasculature morphology ( J:83894 )
• intrarenal arterioles are thickened
decreased systemic arterial systolic blood pressure ( J:83894 )
• 74.6+/-2.7 mmHg compared to 121.1+/-4.3 mmHg in wild-type mice

hematopoietic system
decreased hematocrit ( J:83894 )
• hematocrit levels are reduced 41% relative to wild-type mice




Genotype
MGI:3720680
cx2
Allelic
Composition		 Acetm4Keb/Acetm4Keb
Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic
Background		 involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm4Keb mutation (0 available); any Ace mutation (54 available)
Bdkrb2tm1Jfh mutation (3 available); any Bdkrb2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney vasculature morphology ( J:83894 )
• intrarenal arterioles are thickened as in Acetm4Keb homozygotes
kidney cyst ( J:83894 )
• one mouse exhibited a renal cyst similar as those seen in Bdkrb2 null mice
decreased urine osmolality ( J:83894 )
• mice produce less concentrated urine than in wild-type mice and the difference is exacerbated upon water deprivation

homeostasis/metabolism
decreased urine osmolality ( J:83894 )
• mice produce less concentrated urine than in wild-type mice and the difference is exacerbated upon water deprivation
abnormal response/metabolism to endogenous compounds ( J:83894 )
• mice do not respond to bradykinin infusion as wild-type mice do by way of reduce blood pressure and increased heart rate

cardiovascular system
abnormal kidney vasculature morphology ( J:83894 )
• intrarenal arterioles are thickened as in Acetm4Keb homozygotes
decreased systemic arterial systolic blood pressure ( J:83894 )
• 74.9+/-1.2 mmHg compared to 121.1+/-4.3 mmHg in wild-type mice and similar to that seem in Acetm4Keb homozygotes
vascular inflammation ( J:83894 )
• mice present with perivascular inflammation with focal vasculitis

hematopoietic system
decreased hematocrit ( J:83894 )
• hematocrit levels are reduced 45% relative to wild-type mice

growth/size/body
kidney cyst ( J:83894 )
• one mouse exhibited a renal cyst similar as those seen in Bdkrb2 null mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory