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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ica1tm1Mdos
targeted mutation 1, H Michael Dosch
MGI:2662437
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ica1tm1Mdos/Ica1tm1Mdos involves: 129S1/Sv * 129X1/SvJ MGI:3831658
hm2
 		Ica1tm1Mdos/Ica1tm1Mdos NOD.129-Ica1tm1Mdos MGI:2662441
cx3
 		Ica1tm1Mdos/Ica1tm1Mdos
Ica1lem1Jxia/Ica1lem1Jxia 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5806228


Genotype
MGI:3831658
hm1
Allelic
Composition		 Ica1tm1Mdos/Ica1tm1Mdos
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1tm1Mdos mutation (1 available); any Ica1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:83526 )
• mutants have no obvious phenotype and age normally

reproductive system
reproductive system phenotype ( J:233657 )
N
• mice exhibit normal fertility with no significant difference in total, mobile and linear mobile sperm




Genotype
MGI:2662441
hm2
Allelic
Composition		 Ica1tm1Mdos/Ica1tm1Mdos
Genetic
Background		 NOD.129-Ica1tm1Mdos
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1tm1Mdos mutation (1 available); any Ica1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:83526 )
• a subset of females die spontaneously without prodromal symptoms around 4-5 months of age

homeostasis/metabolism
abnormal glucose homeostasis ( J:83526 )
• diabetes develops around 20 weeks of age, 4 weeks later than wild-type NOD mice

immune system
abnormal T cell physiology ( J:83526 )
• mutants fail to generate, even after immunization, cross-reactive T cells that recognize the dominant Tep69 epitope in Ica1, and the ABBOS epitope in BSA
decreased susceptibility to autoimmune diabetes ( J:83526 )
• although mutants develop diabetes at around 20 weeks of age, this is 4 weeks later than wild-type NOD mice
• mutants are resistant to cyclophosphamide-accelerated diabetes

hematopoietic system
abnormal T cell physiology ( J:83526 )
• mutants fail to generate, even after immunization, cross-reactive T cells that recognize the dominant Tep69 epitope in Ica1, and the ABBOS epitope in BSA




Genotype
MGI:5806228
cx3
Allelic
Composition		 Ica1tm1Mdos/Ica1tm1Mdos
Ica1lem1Jxia/Ica1lem1Jxia
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ica1lem1Jxia mutation (0 available); any Ica1l mutation (23 available)
Ica1tm1Mdos mutation (1 available); any Ica1 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:233657 )
• severe reduction in total and mobile sperm number with complete loss of linear mobile sperm
• in cauda epididymis
abnormal acrosome morphology ( J:233657 )
• fragmented or completely lost
absent acrosome ( J:233657 )
• in some sperm
abnormal sperm nucleus morphology ( J:233657 )
• smaller and irregular compared with wild-type sperm
abnormal spermiogenesis ( J:233657 )
• with round nuclei sperm

cellular
oligozoospermia ( J:233657 )
• severe reduction in total and mobile sperm number with complete loss of linear mobile sperm
• in cauda epididymis
abnormal acrosome morphology ( J:233657 )
• fragmented or completely lost
absent acrosome ( J:233657 )
• in some sperm
abnormal sperm nucleus morphology ( J:233657 )
• smaller and irregular compared with wild-type sperm




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory