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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rtn4tm1Matl
targeted mutation 1, Marc Tessier-Lavigne
MGI:2661136
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rtn4tm1Matl/Rtn4tm1Matl involves: 129S7/SvEvBrd * C57BL/6 MGI:2661219
cn2
 		Nus1tm1Wcsa/Nus1+
Rtn4tm1Matl/Rtn4tm1Matl
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: 129S7/SvEvBrd MGI:6361104


Genotype
MGI:2661219
hm1
Allelic
Composition		 Rtn4tm1Matl/Rtn4tm1Matl
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4tm1Matl mutation (1 available); any Rtn4 mutation (130 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system physiology ( J:83192 )
• myelin from mutants has reduced inhibitory activity in a neurite outgrowth assay in vitro compared to wild-type myelin
• however, mutants are viable, fertile and indistinguishable from wild-type and do not exhibit enhanced regeneration of corticospinal tract axons after spinal cord injury




Genotype
MGI:6361104
cn2
Allelic
Composition		 Nus1tm1Wcsa/Nus1+
Rtn4tm1Matl/Rtn4tm1Matl
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1Wcsa mutation (0 available); any Nus1 mutation (19 available)
Rtn4tm1Matl mutation (1 available); any Rtn4 mutation (130 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:230506 )
N
• embryos from tamoxifen-treated pregnant females at E8.5 do not show vascular defects




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory