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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otx2tm6.1Asim
targeted mutation 6.1, Antonio Simeone
MGI:2661067
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Otx1tm4(cre)Asim/Otx1+
Otx2tm6Asim/Otx2tm6.1Asim 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:2661066


Genotype
MGI:2661066
cn1
Allelic
Composition		 Otx1tm4(cre)Asim/Otx1+
Otx2tm6Asim/Otx2tm6.1Asim
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx1tm4(cre)Asim mutation (2 available); any Otx1 mutation (88 available)
Otx2tm6.1Asim mutation (0 available); any Otx2 mutation (51 available)
Otx2tm6Asim mutation (1 available); any Otx2 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:83110 )
• all mutants die at birth

nervous system
abnormal neuronal precursor proliferation ( J:83110 )
• proliferating neuroblasts are increased in number in floor plate neuroepithelium at E12.5
abnormal midbrain-hindbrain boundary morphology ( J:83110 )
• isthmus is reduced in size and thickness at E18.5
small tectum ( J:83110 )
• posterior tectum is reduced in size and thickness at E18.5
abnormal tegmentum morphology ( J:83110 )
• tegmentum is enlarged at E18.5

cellular
abnormal neuronal precursor proliferation ( J:83110 )
• proliferating neuroblasts are increased in number in floor plate neuroepithelium at E12.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory