About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otx2tm6.1Asim
targeted mutation 6.1, Antonio Simeone
MGI:2661067
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Otx1tm4(cre)Asim/Otx1+
Otx2tm6Asim/Otx2tm6.1Asim 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:2661066


Genotype
MGI:2661066
cn1
Allelic
Composition		 Otx1tm4(cre)Asim/Otx1+
Otx2tm6Asim/Otx2tm6.1Asim
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx1tm4(cre)Asim mutation (2 available); any Otx1 mutation (86 available)
Otx2tm6.1Asim mutation (0 available); any Otx2 mutation (50 available)
Otx2tm6Asim mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:83110 )
• all mutants die at birth

nervous system
abnormal neuronal precursor proliferation ( J:83110 )
• proliferating neuroblasts are increased in number in floor plate neuroepithelium at E12.5
abnormal midbrain-hindbrain boundary morphology ( J:83110 )
• isthmus is reduced in size and thickness at E18.5
small tectum ( J:83110 )
• posterior tectum is reduced in size and thickness at E18.5
abnormal tegmentum morphology ( J:83110 )
• tegmentum is enlarged at E18.5

cellular
abnormal neuronal precursor proliferation ( J:83110 )
• proliferating neuroblasts are increased in number in floor plate neuroepithelium at E12.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory