Analysis Tools
hematopoietic system
immune system
endocrine/exocrine glands
|
Allele Symbol Allele Name Allele ID |
Gfi1tm1Tmo targeted mutation 1, Tarik Moroy MGI:2660761 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• animals die between 2-3 months of age
|
|
• mutants weigh 10%-50% less than wild-type
|
|
• impaired pre-T cell development
|
|
• impaired granulocyte differentiation
|
|
• accumulation of immature monocytes in the blood and bone marrow
|
|
• near complete absence of granulocytes in blood and bone marrow
|
|
• homozygotes are severely neutropenic
|
|
• decrease in frequency of B cells in lymph nodes and spleen
|
|
• decrease in frequency of mature T cells in lymph nodes and spleen
|
|
• thymic cell numbers are 10% that of wild-type
|
|
• impaired pre-T cell development
|
|
• impaired granulocyte differentiation
|
|
• accumulation of immature monocytes in the blood and bone marrow
|
|
• near complete absence of granulocytes in blood and bone marrow
|
|
• homozygotes are severely neutropenic
|
|
• decrease in frequency of B cells in lymph nodes and spleen
|
|
• decrease in frequency of mature T cells in lymph nodes and spleen
|
|
• thymic cell numbers are 10% that of wild-type
|
|
• increased IL-1beta production in response to low dose LPS challenge
|
|
• increased IL-10 production in response to low dose LPS challenge
|
|
• increased Tnf production in response to low dose LPS challenge
|
|
• increased inflammatory response when challenged with a low dose of LPS, animals died from endotoxic shock within 28 hours
|
|
• at E18.5, IHCs are clearly identified both at the base and the apex of the cochlea, but appear smaller and more immature relative to wild-type IHCs
|
|
• at E18.5, apical extensions, presumably primordia of stereociliary bundles, appear shorter and less organized
|
|
• at E18.5, IHC stereociliary bundles appear shorter
|
|
• at E18.5, OHC morphology and patterning is markedly abnormal
|
|
• at E18.5, no intact OHC stereociliary bundles can be identified with phalloidin staining
• at E18.5 or P0, the luminal surface of OHCs throughout the length of the cochlea is composed of a sheath of poorly differentiated and disorganized apical projections and poorly defined cell boundaries
|
|
• at E18.5, homozygotes exhibit OHC degeneration in the base and apex of the cochlea; less severe OHC degeneration is noted at E16.5
• in contrast, IHCs are readily identified along the entire length of the cochlea and the pillar cell row is undisrupted in the basal region
|
|
• homozygotes exhibit vestibular dysfunction due to hair cell loss
|
|
• at E18.5, IHCs are clearly identified both at the base and the apex of the cochlea, but appear smaller and more immature relative to wild-type IHCs
|
|
• at E18.5, apical extensions, presumably primordia of stereociliary bundles, appear shorter and less organized
|
|
• at E18.5, IHC stereociliary bundles appear shorter
|
|
• at E18.5, OHC morphology and patterning is markedly abnormal
|
|
• at E18.5, no intact OHC stereociliary bundles can be identified with phalloidin staining
• at E18.5 or P0, the luminal surface of OHCs throughout the length of the cochlea is composed of a sheath of poorly differentiated and disorganized apical projections and poorly defined cell boundaries
|
|
• at E18.5, homozygotes exhibit OHC degeneration in the base and apex of the cochlea; less severe OHC degeneration is noted at E16.5
• in contrast, IHCs are readily identified along the entire length of the cochlea and the pillar cell row is undisrupted in the basal region
|
|
• impaired granulocyte differentiation
|
|
• accumulation of immature monocytes in the blood and bone marrow
|
|
• thymic cell numbers are 10% that of wild-type
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/23/2024 MGI 6.23 |
|
|
|
||